Evidence map›Paper›PMID 40486019›Full record

ReviewMedical journal of the Islamic Republic of Iran2025

Biological Basis for the Formation of Suicidal Behavior: A Review.

Roza Tatayeva, Yerbol Nurkatov, Lyailya Akbayeva, Oralbek Ilderbayev, Akmaral Makhanova, Ainash Suleimenova

Abstract readReview
In one paragraph

Review in Medical journal of the Islamic Republic of Iran, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Epigenetic Mechanisms of Suicidal Behavior Formation: A Review.Medical journal of the Islamic Republic of Iran · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Roza TatayevaDepartment of General Biology and Genomics, L.N. Gumilyov Eurasian National University, Astana , Kazakhstan.ORCID https://orcid.org/0000-0001-8260-7786
Yerbol NurkatovDepartment of Health and Wellness Center, Nazarbayev University, Astana, Kazakhstan.
Lyailya AkbayevaDepartment of General Biology and Genomics, L.N. Gumilyov Eurasian National University, Astana , Kazakhstan.
Oralbek IlderbayevDepartment of General Biology and Genomics, L.N. Gumilyov Eurasian National University, Astana , Kazakhstan.
Akmaral MakhanovaMedical University of Karaganda, Karaganda, Kazakhstan.
Ainash SuleimenovaDepartment of General Biology and Genomics, L.N. Gumilyov Eurasian National University, Astana , Kazakhstan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The article addresses one of the pivotal issues in the formation of suicidal behavior, namely the function of central and peripheral neurotransmitter systems and the mechanisms of neuroendocrine regulation. This article presents the relationship between alterations in lipid metabolism and suicidal behavior, as well as candidate genes of the serotonergic system involved in suicidal behavior. Methods: The present study is a review of a number of published completed papers by systematically searching original articles in English in the following electronic databases: PubMed, SCOPUS, Mendeley, Google Scholar, and ScienceDirect between 2013 and 2023. Results: A total of 126 sources were used in the scientific literature review, covering findings from a range of disciplines, including biology, neurochemistry, anatomy, neurohormones, and serotonergic system candidate genes relevant to suicidal behavior. Conclusion: The identification of neurobiological indicators of suicidality is of significant importance for the understanding of the pathophysiology of suicidality and for the search for peripheral markers that could be utilized to clarify risk, prediction, and, ideally, suicide prevention. The findings of this review underscore the intricate biological underpinnings of suicidal behavior, underscoring that suicidality is not merely a psychological or social phenomenon but rather a complex and deeply rooted system of neurobiological processes. The review suggests that biological markers should be integrated with existing psychological assessments to create a multidimensional profile of suicide risk.

Indexed as

Candidate GenesCortisolLipid ProfileSerotoninSuicide

Identifiers

PMID40486019
PMCPMC12138780

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.