ArticleResearch and practice in thrombosis and haemostasis2025
C-type lectin-like receptor 2 in platelets amplifies inflammation in rheumatoid arthritis.
Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Regulation of basal and tumour necrosis factor α-induced fibroblast gene expression by peptidylarginine deiminase 2.The Journal of physiology · 2026Article
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11 authors.
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Abstract
Background: Platelets play a crucial role not only in thrombosis and hemostasis but also in inflammation, including rheumatoid arthritis. Although synovial cells in the joints express the membrane protein podoplanin, and platelets express the podoplanin receptor C-type lectin-like receptor 2 (CLEC-2), the role of CLEC-2 in arthritis has not been elucidated. Objectives: This study investigated the role of CLEC-2 in arthritis. Methods: Fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis were cocultured with washed human platelets, activated platelet supernatants, or recombinant CLEC-2 (rCLEC-2) to assess FLS proliferation and inflammatory cytokine mRNA levels. A KRN/B6xNOD (K/BxN) mice serum-transfer arthritis (STA) mouse model was used to study the in vivo roles of CLEC-2/podoplanin. Radiation bone marrow chimeric mice were generated by transplanting fetal liver cells from platelet/megakaryocyte-specific CLEC-2 conditional knockout (cKO) or wild-type (WT) embryos, to which serum from K/BxN was transferred. Arthritis was assessed by measuring the thicknesses of all 4 limbs. Results: Coculture with platelets or rCLEC-2 significantly enhanced FLS proliferation and increased the mRNA levels of inflammatory cytokines including IL-6, IL-8, CXCL-2, CXCL-3, IL-1β, and tumour necrosis factor-α. Furthermore, platelets from wild-type mice showed increased mRNA levels of these cytokines in mouse FLSs. CLEC-2-deficient platelets partially, but significantly, inhibited this effect. In the STA model, CLEC-2 cKO mice showed reduced arthritis compared to WT mice. Immunohistological analysis confirmed the presence of platelets in the proliferative synovium. Conclusion: CLEC-2 amplified arthritic platelets by stimulating the production of inflammatory cytokines and cell proliferation in FLSs.
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