ReviewCureus2025
Association of Triglyceride-Glucose (TyG) Index With Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Article
- Triglyceride-glucose and TyG-BMI indexes predict acute pancreatitis in adult critically ill patients admitted to intensive care.Clinics (Sao Paulo, Brazil) · 2026Article
- Comparative analysis of four nutritional scores in predicting hospital stay duration for EICU Patients with acute pancreatitis.Frontiers in nutrition · 2026Article
- Diagnostic and Prognostic Value of miR-574-3p in Acute Pancreatitis: Insights from Bioinformatics and in vitro Studies.Journal of inflammation research · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The triglyceride-glucose (TyG) index has emerged as a surrogate marker for insulin resistance and has been implicated in various metabolic and inflammatory diseases. Its potential role in predicting the severity of acute pancreatitis (AP), particularly severe acute pancreatitis (SAP), remains underexplored. This study aims to evaluate the association between the TyG index and SAP through a systematic review and meta-analysis. We systematically searched PubMed, Scopus, and Europe PMC databases from inception to March 26, 2025. Eligible studies included adult patients with AP stratified by severity (SAP vs. non-SAP) and reported TyG index values. Data extraction and quality assessment using the Newcastle-Ottawa Scale were conducted independently by two reviewers. A random-effects model was used to compute pooled mean differences (MD), with subgroup and sensitivity analyses to explore heterogeneity. Ten studies comprising 2262 patients were included. The TyG index was significantly higher in SAP patients compared to non-SAP patients (MD = 0.61; 95% CI: 0.46-0.76; p < 0.0001; I² = 79.1%). The index also predicted ICU admission (MD = 0.52) and mortality (MD = 0.71) in AP patients. Subgroup analyses showed consistent findings across study designs and sample sizes, though geographic variability was observed. The TyG index is significantly associated with the severity of AP and may serve as a reliable, accessible prognostic biomarker for identifying patients at risk of SAP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.