Observational studyFrontiers in immunology2025
Changes in immune cell signatures during early infection reflect decoupling of capillary perfusion and glycocalyx dimensions.
Observational study in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Converging evidence for a two-domain framework of microvascular dysfunction in sepsis.Critical care (London, England) · 2026Article
- Early detection of glycocalyx and microvascular damage in suspected sepsis in the emergency department: the EDGE study.Critical care (London, England) · 2026Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Microvascular injury is central to the pathophysiology of sepsis, but its interaction with the immune system in early infection is unclear. This study aimed to phenotype peripheral blood mononuclear cells (PBMC) from emergency department (ED) patients with suspected bacterial infection and correlate the results with microvascular changes. Methods: This prospective observational study included 49 adult ED patients with suspected infection and 17 healthy controls. Capillary density and glycocalyx dimensions were measured by sublingual microscopy, while peripheral blood immune cell subsets were analyzed by deep flow cytometry. Results: Network visualization of 72 diIerentially regulated parameters revealed specific changes in diIerent immune cell subsets. Innate immune changes included a functional diversion of monocytes towards pathogen defense and tissue repair, whereas adaptive immune changes included the development of CD4+ T cells with Th2-profile and cytotoxic CD8+ T cells. Unsupervised clustering revealed two distinct immune endotypes: E1 with a suppressed immune response and higher disease severity, and E2 with an enhanced immune response and lower disease severity. Patients showed significant reductions in capillary density and glycocalyx dimensions, which were neither correlated in magnitude nor associated with endotypes. There was a strong association between damaged glycocalyx and several monocyte and T-cell subsets. This association was not observed for capillary density. Discussion: We demonstrate that glycocalyx damage is associated with a unique immunological signature, distinct from functional capillary density. These findings provide a strong basis for future studies of immune dysregulation and microvascular dysfunction in infection.
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