ReviewAnnals of medicine and surgery (2012)2025
Stress, neutrophils, and immunity: a dynamic interplay.
Review in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Fast and slow gene expression changes in blood following acute social stress.Brain, behavior, & immunity - health · 2026Article
- Advances in salivary cortisol monitoring for healthcare applications.RSC advances · 2026Review
- Safety Signals of CRS and ICANS With Tarlatamab in Relapsed Small Cell Lung Cancer: Insights From a Small Case Study.Thoracic cancer · 2026Article
- Terpenes as Potential Multi-Target Modulators of Chronic Stress-Induced Neuroendocrine-Immune Dysregulation.International journal of molecular sciences · 2026Review
- Neuropeptide Y in cancer metastasis and chemoresistance.Neuropeptides · 2026Review
- Immunomodulatory effect of stress hormones on porcine neutrophil functions during Actinobacillus pleuropneumoniae infection.Medical microbiology and immunology · 2026Article
- Methylome-wide association study in blood suggests cell type-specific relationships between DNA methylation and lifetime anxiety.Nature communications · 2026Article
- Article
- Roles of anesthetics in modulating neutrophil extracellular traps formation: a review of current literature.Annals of medicine and surgery (2012) · 2026Article
- Neutrophils and NETosis in polycystic ovary syndrome: unraveling the immuno-metabolic thromboinflammatory axis.European journal of medical research · 2026Review
- Dynamic impacts of COVID-19 on immune cells and inflammatory indicators in Chinese medical health workers: a retrospective longitudinal study.Frontiers in cellular and infection microbiology · 2026Article
- Molecular cytokine-dependent mechanisms of periodontitis pathogenesis and the potential for pharmacological IL-1 modulation in disease treatment.Frontiers in dental medicine · 2026Review
- Effect of chronic stress on human endocrine function: A biomarker-based study.Bioinformation · 2026Article
- Glucocorticoids and Neutrophil Biology: Impact on the Development of Resistance to Glucocorticoid Therapy.Neuroimmunomodulation · 2026Review
- Inflammatory marker dynamics in shift work sleep disorder: a data-driven approach among rotating shift workers.Frontiers in neuroscience · 2026Article
- Review
- Assessment of frailty and inflammatory burden index as predictors of postoperative IAA in elderly appendectomy patients.BMC surgery · 2025Article
- Chronic Restraint Stress Misaligns Corneal Clock via β-Adrenergic and Glucocorticoid Signaling, Altering Epithelial, Neural, Immune, Metabolic States.Investigative ophthalmology & visual science · 2025Article
- NETs in ovarian cancer progression: innovative nanoparticle-based therapeutic strategies.European journal of medical research · 2025Review
- Silent Inflammation, Loud Consequences: Decoding NLR Across Renal, Cardiovascular and Metabolic Disorders.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophils, the most abundant type of white blood cells, are pivotal players in the innate immune system, responsible for rapid responses to infection and tissue damage. They engage in various defensive activities, including phagocytosis, degranulation, and the formation of neutrophil extracellular traps (NETs). Stress, encompassing both physiological and psychological forms, significantly influences the immune system, notably impacting neutrophil function. This review delves into the intricate interplay between stress, neutrophils, and immunity, underscoring how stress modulates neutrophil activity and the broader implications for immune health. The body's response to stress involves the activation of the hypothalamic-pituitary-adrenal (HPA) axis and the subsequent release of stress hormones such as cortisol and adrenaline. These hormones can enhance or suppress immune functions, depending on the nature and duration of the stress. Acute stress may temporarily boost neutrophil activity, enhancing the body's immediate defense mechanisms. In contrast, chronic stress typically results in immunosuppression, adversely affecting neutrophil functions and increasing vulnerability to infections and inflammatory diseases. The mechanisms through which stress affects neutrophils include hormonal regulation, neuroimmune interactions, and alterations in the production of inflammatory mediators. The dynamic relationship between stress and neutrophils has significant health implications. While acute stress can enhance immune defenses, chronic stress contributes to a range of health issues, including increased infection risk, autoimmune disorders, and chronic inflammatory conditions such as cardiovascular disease and cancer.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.