ArticleFrontiers in genetics2025
The role of E2F1 in promoting EIF4EBP1 transcription in cryptorchid mice: association with autophagy in germ cells.
Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Cryptorchidism can cause excessive germ cell autophagy and apoptosis to impair fertility. This study investigates the role of E2F1 in regulating EIF4EBP1 expression and its contribution to excessive autophagy and apoptosis in cryptorchidism. Methods: A cryptorchidism mouse model was established through surgical intervention, while an Results: In the cryptorchidism mouse model, reduced testicular volume and weight, increased testicular damage and fibrosis, decreased testosterone levels, and impaired sperm count and vitality were observed. In the Conclusion: E2F1 regulates EIF4EBP1 expression in cryptorchidism, contributing to excessive autophagy and apoptosis. Inhibiting E2F1 reduces these pathological processes, alleviating testicular damage and improving fertility, highlighting potential therapeutic targets for cryptorchidism.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.