Evidence map›Paper›PMID 40487241›Full record

ArticleBioactive materials2025

Subaqueous acoustic pressure system based one day heterotypic pseudo-islet spheroid formation with adipose derived stem cells for graft survival-related function enhancement.

Jiyu Hyun, Junhyeung Park, Jihun Song, Chaerim Yoo, Seonmi Jang, Sang Yoon Lee, Jiseon An, Hyun Su Park, Seunghyuk Jung, Dasom Kong and 8 more

Abstract read
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In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jiyu HyunSchool of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Junhyeung ParkDepartment of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Jihun SongBiomedical Research Center, Korea University Guro Hospital, Seoul, Republic of Korea.
Chaerim YooDepartment of Bioengineering, College of Engineering, Hanyang University, Seoul, 04763, Republic of Korea.
Seonmi JangDepartment of Bioengineering, College of Engineering, Hanyang University, Seoul, 04763, Republic of Korea.
Sang Yoon LeeSchool of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Jiseon AnSchool of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Hyun Su ParkSchool of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Seunghyuk JungDepartment of Applied Chemistry & Biological Engineering, Ajou University, Suwon, 16499, Republic of Korea.
Dasom KongDepartment of Molecular Science and Technology, Ajou University, Suwon, 16499, Republic of Korea.
Ji Hyeon ChoDepartment of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Tae Il LeeDepartment of Materials Science and Engineering, Gachon University, Seong-nam, 13120, Republic of Korea.
Ki Dong ParkDepartment of Molecular Science and Technology, Ajou University, Suwon, 16499, Republic of Korea.
Gwang-Bum ImSchool of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Jee-Heon JeongDepartment of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Hyun-Ji ParkDepartment of Molecular Science and Technology, Ajou University, Suwon, 16499, Republic of Korea.
Dong Yun LeeDepartment of Bioengineering, College of Engineering, Hanyang University, Seoul, 04763, Republic of Korea.
Suk Ho BhangSchool of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To overcome Type 1 diabetes mellitus (T1DM), which can cause hyperglycemia due to diminished insulin secretion of β-cell function, islet transplantation has been developed with various strategies including pseudo-islet. However, conventional pseudo-islet formation techniques combining with other cells depend on natural cellular aggregation, which requires at least 5 days to form and even show segregation of distinct cell types, leading to diminished cell viability and function. Herein, we applied a subaqueous free-standing 3D cell culture (FS) device, which can reduce the spheroid formation time by trapped cell in nodes of acoustic standing wave. Briefly, Culturing with adipose-derived stem cells (ADSCs) to form heterotypic pseudo-islet (Hislet) in FS device dramatically reduced formation time less than one day. Hislet demonstrated enhancement of cell viability than conventional pseudo-islet formation method. Additionally, ADSCs combined Hislet proved strong secretion of various paracrine factors. Also results showed significantly increased angiogenesis effect and immunomodulation effect for various type of immune cells in Hislet compared to islet, which can enhance transplantation survival. Furthermore, Hislet validated glucose-regulating capacity and enhanced angiogenesis effect

Indexed as

Acoustic levitationAdipose-derived stem cellCell culture systemPancreatic isletPseudo isletType 1 diabetes mellitus

Identifiers

PMID40487241
PMCPMC12145519

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.