ReviewBurns & trauma2025
Extracellular vesicles in burn injury: roles, mechanisms, and applications.
Review in Burns & trauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Exosome therapy for flap and skin graft survival: A systematic review and meta-analysis of preclinical evidence.JPRAS open · 2026Review
- Target degradation of CASPASE-1 for alleviation of inflammation in sepsisActa pharmaceutica Sinica. B · 2026Article
- Burn-associated metabolic dysfunction: could extracellular vesicles play a role?Clinical science (London, England : 1979) · 2026Review
- Advanced Regenerative Drainage and Immunomodulatory Protocol for Dermal Filler-Induced Skin Necrosis: A Prospective Clinical Case Series.Journal of cosmetic dermatology · 2026Article
- Endolaser-Induced Cutaneous Necrosis: A Case Report.Cureus · 2025Article
- Extracellular vesicles in chronic wound therapy: engineering strategies and advanced delivery systems for enhanced regeneration.Materials today. Bio · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The morbidity and mortality rate from burn injuries is substantial, and patients might suffer irreparable harm from the several pathophysiological processes that severe burns cause, including metabolic alterations, distributive shock, and inflammatory responses. Prevention of infections, reduction of inflammation, alleviation of pain, and regulation of growth factors are all essential components of burn wound care, yet there are still major challenges. Multiple biological activities rely on extracellular vesicles (EVs), which are lipid bilayer vesicles released by a wide range of cell types (including prokaryotes, plant cells, and mammals). Among these processes are immunomodulation, neovascularization, and cell survival. Due to their rich composition, EVs may carry a variety of active substances, including nucleic acids and proteins, and hence play a pivotal role in many subcellular levels during wound healing. In addition, EVs may be found in a variety of burn damage patients' biofluids, making them potential new biomarkers for tracking the efficacy of treatments and making prognoses assumptions. An overview of the biological functions of EVs and the ways in which they alleviate burn injuries is provided in this paper. Additionally, we cover the likelihood of EVs being used in burn wound treatment in the future. This study aims to inspire and direct future comprehensive research on the use of EVs in burn wound healing, introduce a novel treatment for burn wounds, and serve as a resource for anybody interested in using EVs for clinical wound healing.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.