ArticleF&S reports2025
Outside the box: comparative stem cell insights for fertility biotechnology and conservation.
Article in F&S reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Review
- Oogenesis and germinal bed morphology of the brown anole (A. sagrei).Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Male germ cell technologies in large animals.The Journal of reproduction and development · 2026Review
- Oogenesis and germinal bed morphology of the brown anole (bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leveraging comparative biology could lead to breakthrough discoveries in the development of fertility technologies while supporting conservation efforts. Here, we discuss examples and opportunities to learn from stem cell systems in nontraditional animal models, primarily from the amniote phylum, focusing on challenges and insights in the in vitro derivation of primordial germ cells and gametes, as well as the promise of gonadal stem cells. Embryo models and organoid systems provide a further opportunity to explore germ cell specification and maturation within a proxy 'in vivo' context. Additionally, stem cells enable high-throughput molecular studies to explore the mechanisms underlying fertility-related diseases. Using the international effort to derive gametes from stem cells of the Northern White Rhino as a case study, we highlight the contribution of alternative mammalian systems within the field of assisted reproductive treatments and point toward promising directions for future research. Contextualizing stem cell derivation and differentiation within a comparative species framework will be essential for harnessing the full potential of reproductive technologies for human fertility while simultaneously opening new frontiers in wildlife conservation.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.