Evidence map›Paper›PMID 40487337›Full record

ReviewJournal of orthopaedics2025

The effect of blood flow restriction combined with neuromuscular electrical stimulation on knee joint function: A systematic review and meta-analysis.

Fahed Herbawi, Asmaa Daami, Haneen Ishtayah, Hiba Fakher Al Deen, Maha Nofal, Shaimaa Zaid, Mario Lozano-Lozano, Carolina Fernandez-Lao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of orthopaedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fahed HerbawiDepartment of Applied and Allied Medical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Asmaa DaamiDepartment of Applied and Allied Medical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Haneen IshtayahDepartment of Applied and Allied Medical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Hiba Fakher Al DeenDepartment of Applied and Allied Medical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Maha NofalDepartment of Applied and Allied Medical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Shaimaa ZaidDepartment of Applied and Allied Medical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Mario Lozano-LozanoDepartment of Physical Therapy, Health Science Faculty, University of Granada, Avda de la Ilustración 60, 18016, Granada, Spain.
Carolina Fernandez-LaoDepartment of Physical Therapy, Health Science Faculty, University of Granada, Avda de la Ilustración 60, 18016, Granada, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To determine whether the combined application of blood flow restriction and neuromuscular electrical stimulation significantly affects quadriceps strength, hypertrophy, pain, and fatigue. Design: Systematic review with meta-analysis. Literature search: PubMed, Scopus, and Web of Science from inception to November 2023. Study selection criteria: Randomized and non-randomized full-text human clinical trials published in English investigating the combination between blood flow restriction and neuromuscular electrical stimulation on knee joint. Data synthesis: The correlation data was pooled across studies using a random effects model. Cohen's D was calculated for each original study and an overall estimator, and a two-sided p value < 0.05 was considered statistically significant. Results: Out of 294 records, nine studies with 257 participants were included in the systematic review. A meta-analysis revealed no significant differences in quadriceps strength at two, 3, and 6 weeks. Similarly, it was also shown in hypertrophy at 7-15 min, 2, and 6 weeks. Conclusion: The blood flow restriction combined with neuromuscular electrical stimulation had no additional effect to the original isolated techniques on quadriceps strength and hypertrophy. Moreover, causes higher pain and fatigue levels after its use.

Indexed as

Blood flow restrictionElectrical stimulationHypertrophyKnee jointNeuromuscular electrical stimulationQuadricepsStrengthWeakness

Identifiers

PMID40487337
PMCPMC12139680

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.