Evidence map›Paper›PMID 40487353›Full record

ArticleMolecular therapy. Nucleic acids2025

CircITSN1/EIF4A3/Itsn1 axis mediates postoperative cognitive dysfunction in aged mice: A novel mechanism and therapeutic target.

Changteng Zhang, Xiaoyu Zhu, Rui Gao, Hai Chen, Caiyi Yan, Wangyang Liu, Lina Yang, Xianzheng Zeng, Haoran Yang, Jin Liu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Changteng ZhangDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Xiaoyu ZhuDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Rui GaoDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Hai ChenDepartment of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital 610041, Sichuan University, Chengdu, Sichuan, China.
Caiyi YanDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Wangyang LiuDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Lina YangDepartment of Anesthesiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan, China.
Xianzheng ZengDepartment of Pain Management, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Haoran YangShool of Educational Science, Chongqing Normal University, Chongqing 401331, China.
Jin LiuDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Qi LiDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Daqing MaDivision of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London SW72AZ, UK.
Tao ZhuDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Chan ChenDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) are stable noncoding RNAs that play a crucial role in neurodegenerative diseases, and they have been implicated in the pathogenesis of postoperative cognitive dysfunction (POCD). However, their underlying molecular mechanisms in POCD remain poorly understood. This study identified hsa_circRNA_061570 as significantly upregulated in plasma after anesthesia/surgery using high-throughput circRNA microarray screening, correlating with cognitive decline. Its murine homolog, circITSN1, was further investigated using shRNA-mediated knockdown in the hippocampus. Behavioral tests (open field, Y maze, and fear conditioning) revealed that circITSN1 suppression improved spatial and contextual memory without affecting motor function. Neuronal damage analysis via Golgi staining demonstrated that circITSN1 knockdown alleviated synaptic and dendritic spine impairments. Mechanistically, circITSN1 directly bound to RNA-binding protein EIF4A3, stabilizing

Indexed as

aged micecircITSN1circRNAEIF4A3intersection 1MT: Non-coding RNAspostoperative cognitive dysfunction

Identifiers

PMID40487353
PMCPMC12143668

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.