ReviewFrontiers in pharmacology2025
A potential herbal component for the future treatment of fatty liver disease: Geniposide from gardenia.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Study on the inhibitory effect of geniposide on coxsackievirus and its mechanism.Frontiers in pharmacology · 2026Article
- Impact of gardenia extract on coagulation function in rats with acute myocardial ischemia model.Thrombosis journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonalcoholic fatty liver disease (NAFLD) is a multisystemic metabolic disease whose global incidence is increasing annually; the currently available treatment options are limited to lifestyle alterations and symptomatic treatments, such as hepatoprotective treatments. However, it is difficult for most patients to adhere to strict lifestyle interventions for long periods, and lifestyle interventions alone have limited effects in some patients with moderate-to-severe NAFLD. Regarding traditional Chinese medicine (TCM) treatments, Zhi-Zi-Da-Huang decoction and Zhi-Zi-Huang-Qin decoction are widely used classic formulas for NAFLD. In this article, we present a review of the progress in research on the use of geniposide, the glycoside analog of gardenia, in the treatment of NAFLD. As a natural ingredient, geniposide has good safety and tolerability profiles and a high potential to exert pharmacological effects. We discuss various mechanisms of action of geniposide in the treatment of NAFLD, including decreased insulin resistance via the regulation of key molecules, such as insulin receptor substrate 1 (IRS-1) and glucose transporter type 1 (GLUT1), and the alleviation of oxidative stress via activation of the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) signaling pathway. Geniposide also enhances mitochondrial function by inhibiting uncoupling protein 2 (UCP2)-mediated proton leakage and has anti-inflammatory and antiapoptotic effects. There are no previous studies reporting the various pharmacological mechanisms of geniposide in the treatment of NAFLD. Our study provides new insights into the effects and mechanisms of action of geniposide, but its toxicity, especially its hepatotoxicity, requires further investigation. Geniposide is a potential drug for the treatment of NAFLD, and further research and development are warranted.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.