ArticleiScience2025
Young rat vascular endothelial cells promote neurological recovery of stroke aged rat via HIF-1α.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Wedelolactone Ameliorates Ischemic Stroke by Inhibiting Oxidative Damage and Ferroptosis via HIF-1α/SLC7A11/GPX4 Signaling.Drug design, development and therapy · 2025Article
- Hypoxia-inducible factor 1-alpha: a dual regulator of ferroptosis in ischemic stroke and a promising therapeutic target.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to explore whether vascular endothelial cells (VECs) derived from young rats enhance neurological recovery following ischemic stroke in aged rats. Middle cerebral artery occlusion models were established, and the rats received lateral ventricle injections of VECs isolated from the cerebral cortex of either young or aged rats. Young VECs treatment facilitated neurorestoration in aged rats on days 3, 7, and 21 following cerebral ischemia. Aged subjects treated with young VECs exhibited reduced neuronal apoptosis, smaller infarct volumes, increased microvessel density, and elevated nerve growth factor expression relative to those receiving aged VECs. Protein levels did not differ between age groups on days 1, 3, or 7 post-stroke (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.