Evidence map›Paper›PMID 40487458›Full record

ArticlePublic health action2025

Pulmonary rehabilitation for post-TB lung disease led by TB survivors.

F J Mtei, I Meadows, K Msaji, F Thobias, A Liyoyo, A Kimaro, P M Joseph, C Gitige, O Kaswaga, S Matoi and 13 more

Abstract read
In one paragraph

Article in Public health action, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

F J MteiKibong'oto Infectious Diseases Hospital Kilimanjaro, Tanzania.
I MeadowsDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, USA.
K MsajiKibong'oto Infectious Diseases Hospital Kilimanjaro, Tanzania.
F ThobiasKibong'oto Infectious Diseases Hospital Kilimanjaro, Tanzania.
A LiyoyoKibong'oto Infectious Diseases Hospital Kilimanjaro, Tanzania.
A KimaroKibong'oto Infectious Diseases Hospital Kilimanjaro, Tanzania.
P M JosephKibong'oto Infectious Diseases Hospital Kilimanjaro, Tanzania.
C GitigeKibong'oto Infectious Diseases Hospital Kilimanjaro, Tanzania.
O KaswagaKibong'oto Infectious Diseases Hospital Kilimanjaro, Tanzania.
S MatoiKibong'oto Infectious Diseases Hospital Kilimanjaro, Tanzania.
A NgomaKibong'oto Infectious Diseases Hospital Kilimanjaro, Tanzania.
A MbuyaKibong'oto Infectious Diseases Hospital Kilimanjaro, Tanzania.
P MbeleleKibong'oto Infectious Diseases Hospital Kilimanjaro, Tanzania.
L RitteKibong'oto Infectious Diseases Hospital Kilimanjaro, Tanzania.
L SubiKibong'oto Infectious Diseases Hospital Kilimanjaro, Tanzania.
P NeemaMinistry of Health, National Tuberculosis and Leprosy Programme, Dodoma,Tanzania.
R KisongaMinistry of Health, National Tuberculosis and Leprosy Programme, Dodoma,Tanzania.
D MbwanaMKUTA National TB/HIV Patients Organization, Dar es Salam, Tanzania.
E MpolyaThe Nelson Mandela African Institution of Science and Technology (NM-AIST), Arusha, Tanzania.
M DrageLHL International, Oslo, Norway.
L I LochtingLHL International, Oslo, Norway.
S K HeysellDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, USA.
S G MpagamaKibong'oto Infectious Diseases Hospital Kilimanjaro, Tanzania.

Funding

INFECTIOUS DISEASES TRAINING PROGRAMT32AI007046 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Alison K Criss, William A Petri · 1985 to 2026
$15.3M
Urine Colorimetry for Tuberculosis Pharmacokinetics Evaluation in Children and AdultsR01AI137080 · NIAID · UNIVERSITY OF VIRGINIA · PI Scott K Heysell, Leonid Kagan · 2018 to 2026
$6.3M
Developing research leaders at the intersection of malnutrition and tuberculosis in TanzaniaD43TW012247 · FIC · UNIVERSITY OF VIRGINIA · PI Scott K Heysell, STELLAH GEORGE MPAGAMA · 2022 to 2026
$1.4M
A global Infectious diseases framework to grow interdisciplinary researchK24AI187675 · NIAID · UNIVERSITY OF VIRGINIA · PI Scott K Heysell · 2025 to 2026
$292k
FIC NIH HHS D43 TW012247NIAID NIH HHS K24 AI187675NIAID NIH HHS L30 AI186135NIAID NIH HHS R01 AI137080NIAID NIH HHS T32 AI007046
6 · The paper itself

Abstract

backgroundPost-TB patients often experience persistent lung issues that impair exercise capacity and quality of life. Although pulmonary rehabilitation is known to be effective for chronic lung diseases, its role in post-TB lung disease remains underexplored in high TB-burden settings.

methodThis prospective study (2021-2022) in Tanzania's Kilimanjaro region evaluated a 24-week, community-based pulmonary rehabilitation program led by TB survivors for adults with moderate-to-severe respiratory symptoms despite TB cure. The program included supervised exercise, breathing training, psychosocial support and smoking cessation. Outcomes measured at baseline, 12 weeks, and 24 weeks included spirometry, 6-minute walk distance (6MWD), St. George's Respiratory Questionnaire (SGRQ), BMI, Generalized Anxiety Disorder-7 (GAD-7), and Patient Health Questionnaire-9 (PHQ-9).

resultsAmong 121 participants (mean age 48±8.67 years, 89.2% male), significant improvements were observed in 6MWD (420 vs. 460 meters, p < 0.001) and SGRQ scores (34.63 to 12.99, p < 0.001). Smoking history predicted SGRQ improvement. Although no changes were seen in lung function or BMI, anxiety and depression symptoms improved in those with abnormal baseline scores.

conclusionCommunity-based pulmonary rehabilitation improved symptomatic individuals' quality of life, physical capacity and mental health. Future research should refine intervention timing and evaluate long-term outcomes across diverse settings.

Indexed as

6 minute walk distance (6MWD)lung healthpulmonary function testSGRQSt Georges respiratory questionnairesTanzaniatuberculosis

Identifiers

PMID40487458
PMCPMC12143242

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.