Evidence map›Paper›PMID 40487531›Full record

ArticleFrontiers in public health2025

Associations between blood ethylene oxide levels and bone mineral density.

Wenwen Chen, Sujuan Lu, Min Lin, Kun Chen, Feng Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wenwen ChenShengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
Sujuan LuDepartment of Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Min LinShengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
Kun ChenDepartment of Thoracic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
Feng HuangShengli Clinical Medical College of Fujian Medical University, Fuzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ethylene oxide (EO) is a toxic compound extensively used in industrial applications. This study quantified serum EO levels by measuring hemoglobin-bound ethylene oxide (HbEO). However, the link between bone mineral density (BMD) and HbEO levels remains unexplored. Methods: A total of 2,570 participants were evaluated using data from National Health and Nutrition Examination Survey (NHANES) (2015-2018). Generalized linear regression models (LRM) and restricted cubic spline (RCS) analyses were used to investigate the association between blood EO levels and BMD. Adjusted models were also applied for comprehensive analysis. Results: Blood EO levels and BMD were inversely related ( Conclusion: This study highlights a substantial correlation between EO exposure and BMD. Further randomized controlled trials are required to establish a causal relationship.

Indexed as

Bone DensityEnvironmental ExposureEthylene OxideAdultAgedFemaleHumansMaleMiddle AgedNutrition SurveysEthylene Oxidebone mineral densityethylene oxideinflammationNHANESoxidative stress

Identifiers

PMID40487531
PMCPMC12142054

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.