Evidence map›Paper›PMID 40487568›Full record

ArticleDEN open2026

Impact of Non-Anesthesiologist-Administered Propofol Sedation for Outpatient Endoscopy in the Healthcare System.

Francesco Vito Mandarino, Giorgia Gribaudo, Noemi Salmeri, Lorella Fanti, Alberto Barchi, Luca Massimino, Ernesto Fasulo, Giuseppe Dell'Anna, Francesco Azzolini, Edi Viale and 7 more

Abstract read
In one paragraph

Article in DEN open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Francesco Vito MandarinoDepartment of Gastroenterology and Gastrointestinal Endoscopy IRCCS San Raffaele Hospital Milan Italy.ORCID https://orcid.org/0000-0002-9931-7221
Giorgia GribaudoResearch Centre on Public Health (CESP) University of Milan-Bicocca Monza Italy.
Noemi SalmeriDepartment of Clinical Sciences and Community Health University of Milan Milan Italy.
Lorella FantiDepartment of Gastroenterology and Gastrointestinal Endoscopy IRCCS San Raffaele Hospital Milan Italy.
Alberto BarchiDepartment of Gastroenterology and Gastrointestinal Endoscopy IRCCS San Raffaele Hospital Milan Italy.
Luca MassiminoDepartment of Gastroenterology and Gastrointestinal Endoscopy IRCCS San Raffaele Hospital Milan Italy.
Ernesto FasuloDepartment of Gastroenterology and Gastrointestinal Endoscopy IRCCS San Raffaele Hospital Milan Italy.ORCID https://orcid.org/0009-0009-3967-2684
Giuseppe Dell'AnnaDepartment of Gastroenterology and Gastrointestinal Endoscopy IRCCS San Raffaele Hospital Milan Italy.
Francesco AzzoliniDepartment of Gastroenterology and Gastrointestinal Endoscopy IRCCS San Raffaele Hospital Milan Italy.
Edi VialeDepartment of Gastroenterology and Gastrointestinal Endoscopy IRCCS San Raffaele Hospital Milan Italy.
Edoardo VespaDepartment of Gastroenterology and Gastrointestinal Endoscopy IRCCS San Raffaele Hospital Milan Italy.
Lorenzo QuarioDepartment of Anaesthesiology IRCCS San Raffaele Hospital Milan Italy.
Antonio FacciorussoGastroenterology Unit, University of Lecce Lecce Italy.
Lorenzo FuccioDepartment of Medical and Surgical Sciences University of Bologna Bologna Italy.
Lorenzo Giovanni MantovaniResearch Centre on Public Health (CESP) University of Milan-Bicocca Monza Italy.
Paolo Angelo CortesiResearch Centre on Public Health (CESP) University of Milan-Bicocca Monza Italy.
Silvio DaneseDepartment of Gastroenterology and Gastrointestinal Endoscopy IRCCS San Raffaele Hospital Milan Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Non-anesthesiologist-administered propofol (NAAP) sedation for outpatient endoscopy has proven to be safe. However, implementing NAAP in Western countries faces challenges, and propofol-based sedation is still largely administered by anesthetists. For low-risk patients, anesthesiologist-administered propofol (AAP) could represent an avoidable waste of healthcare resources. Methods: This research consisted of two phases. The first is a retrospective study comparing NAAP and AAP for outpatient endoscopy at a tertiary center, with the primary outcome being the rate of adverse events (AEs). Propensity score matching was performed to balance baseline characteristics between the two groups. The second phase involved a budget impact model to assess the economic impact of using NAAP instead of AAP for low-risk patients, both locally and nationally, between 2023 and 2025. Results: Between May 2019 and November 2021, 2721 patients undergoing esophagogastroduodenoscopies (EGDs; NAAP 2439 and AAP 282) and 2748 colonoscopies (NAAP 2491 and AAP 257) were enrolled. Overall, the AE rates were similar between the cohorts (esophagogastroduodenoscopies: NAAP 1.1% vs. AAP 0.8%, Conclusion: NAAP has a comparable AE rate to AAP for low-risk outpatient endoscopy. Implementing NAAP instead of AAP could save over €100 million and 2000 working days for the Italian NHS between 2023 and 2025. Wider adoption could improve healthcare resource allocation.

Indexed as

costsendoscopynon‐anesthesiologist‐administered propofolpropofolsedation

Identifiers

PMID40487568
PMCPMC12140971

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.