Evidence map›Paper›PMID 40488039›Full record

ArticleACS omega2025

Molecular Modeling and

Marciéli Fabris, Priscila G Camargo, Mariana L Silva, Camilo H S Lima, Magaly G Albuquerque, Carlos R Rodrigues, Nailton M Nascimento-Júnior, Marcelle L F Bispo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marciéli FabrisLaboratório de Síntese de Moléculas Medicinais (LaSMMed), Departamento de Química, Universidade Estadual de Londrina (UEL), Rodovia Celso Garcia Cid, PR-445, Km 380, Londrina, Paraná 86057-970, Brasil.
Priscila G CamargoFaculdade de Farmácia, Departamento de Fármacos e Medicamentos, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373, Rio de Janeiro, Rio de Janeiro 21941-170, Brasil.
Mariana L SilvaLaboratório de Síntese de Moléculas Medicinais (LaSMMed), Departamento de Química, Universidade Estadual de Londrina (UEL), Rodovia Celso Garcia Cid, PR-445, Km 380, Londrina, Paraná 86057-970, Brasil.
Camilo H S LimaLaboratório de Modelagem Molecular (LabMMol), Instituto de Química, Universidade Federal do Rio de Janeiro, Avenida Athos da Silveira Ramos, no 149, Rio de Janeiro, Rio de Janeiro 21941-909, Brasil.ORCID https://orcid.org/0000-0002-5579-7809
Magaly G AlbuquerqueLaboratório de Modelagem Molecular (LabMMol), Instituto de Química, Universidade Federal do Rio de Janeiro, Avenida Athos da Silveira Ramos, no 149, Rio de Janeiro, Rio de Janeiro 21941-909, Brasil.
Carlos R RodriguesFaculdade de Farmácia, Departamento de Fármacos e Medicamentos, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373, Rio de Janeiro, Rio de Janeiro 21941-170, Brasil.
Nailton M Nascimento-JúniorLaboratório de Química Medicinal, Síntese Orgânica e Modelagem Molecular (LaQMedSOMM), Departamento de Química e Bioquímica, Instituto de Química, Universidade Estadual Paulista (UNESP), Rua Prof. Francisco Degni, 55, Araraquara, São Paulo 14800-060, Brasil.ORCID https://orcid.org/0000-0002-1543-419X
Marcelle L F BispoLaboratório de Síntese de Moléculas Medicinais (LaSMMed), Departamento de Química, Universidade Estadual de Londrina (UEL), Rodovia Celso Garcia Cid, PR-445, Km 380, Londrina, Paraná 86057-970, Brasil.ORCID https://orcid.org/0000-0002-6001-360X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ureases are metalloenzymes found in plants, algae, fungi, and bacteria that are responsible for hydrolyzing urea into carbamate and ammonia. The bacterium Helicobacter pylori, which is associated with gastrointestinal disorders, produces large amounts of urease to neutralize stomach acidity. The rising antibiotic resistance of H. pylori presents a significant challenge for eradication efforts, highlighting the need for novel therapeutic strategies. In this study, we explored the LaSMMed chemical library to identify new urease inhibitors. Virtual screening identified six thioureas derived from cinnamic acid (

Identifiers

PMID40488039
PMCPMC12138827

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.