Evidence mapPaperPMID 40488174Full record

ArticleResearch and practice in thrombosis and haemostasis2025

Thrombotic risk determined by

Eric Manderstedt, Christer Halldén, Christina Lind-Halldén, Johan Elf, Peter J Svensson, Gunnar Engström, Olle Melander, Aris Baras, Luca A Lotta, Regeneron Genetics Center4 and 2 more

Abstract read
In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eric ManderstedtCenter for Primary Health Care Research, Lund University and Region Skåne, Malmö, Sweden.
Christer HalldénCenter for Primary Health Care Research, Lund University and Region Skåne, Malmö, Sweden.
Christina Lind-HalldénDepartment of Bioanalysis, Kristianstad University, Kristianstad, Sweden.
Johan ElfDepartment of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
Peter J SvenssonDepartment of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
Gunnar EngströmDepartment of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
Olle MelanderDepartment of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
Aris BarasRegeneron Genetics Center, Tarrytown, New York, USA.
Luca A LottaRegeneron Genetics Center, Tarrytown, New York, USA.
Regeneron Genetics Center4
Bengt ZöllerCenter for Primary Health Care Research, Lund University and Region Skåne, Malmö, Sweden.
Regeneron Genetics Center

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Von Willebrand factor (VWF) and coagulation factor VIII (FVIII) plasma levels are associated with increased risk for venous thromboembolism (VTE). Objectives: This study aimed to determine the thrombotic risk of rare and common variants of 27 genes linked to VWF or FVIII plasma levels in genome-wide association studies. Methods: Exon sequences of 27 genes linked to plasma levels of VWF or FVIII in genome-wide association studies were analyzed for common and rare variants in 28,794 subjects without VTE (born during 1923-1950, 60% women), who participated in the Malmö Diet and Cancer study (1991-1996), with a follow-up time until 2018. Hazard ratios (HRs) were determined. Results: None of the 27 genes were associated with VTE in the rare variant collapsing analysis. Three common exon variants were significantly associated with VTE: rs8176719 (frameshift) in Conclusion: The risk score of 3 common variants in

Indexed as

ABO blood-group systemfactor VIIImolecular epidemiologyvenous thromboembolismvon Willebrand factor

Identifiers

PMID40488174
PMCPMC12145703

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.