ArticleJournal of cosmetic dermatology2025
A Novel Nude Mice Model for Studying the Pathogenesis of Keloid.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Metabolic reprogramming and ferroptosis in keloid pathogenesis: new insights for targeted therapy.Molecular biology reports · 2026Review
- A multifunctional injectable nanocomposite hydrogel for precision keloid therapy via ECM remodeling and local pruritus relief.Journal of nanobiotechnology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundKeloid is a common fibroproliferative disorder, often manifesting symptoms such as itching and pain. Given the unique characteristics of keloids, their occurrence is primarily limited to humans, posing difficulties for spontaneous keloid development in animals. Consequently, the creation of animal models has somewhat impeded the comprehensive investigation of keloids.
aimsThe aim is to develop a keloid mouse model that mimics the formation process of human keloids, enabling researchers to gain a deeper understanding of their pathophysiological mechanisms and to explore effective therapeutic approaches.
methodsHuman keloid fibroblasts were isolated, cultured, and subcutaneously injected with Matrigel into nude mice at four concentrations (1 × 10
resultsKeloid-like nodules formed in a cell density-dependent manner, with the highest concentration group (7 × 10
conclusionThe combination of human keloid fibroblasts and Matrigel provides a simple and rational approach for constructing a nude mouse model, offering a reliable animal model for experimental and clinical research on the pathogenesis and treatment strategies of keloids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.