Mitochondrial DNA Haplogroups, Biomarkers of Inflammation and Immune Activation, and Risk of Diabetes in Veterans With and Without Human Immunodeficiency Virus.
Aiwei Yan, Suman Kundu, David C Samuels, Samuel Bailin, Ke Xu, Kaku So-Armah, Adeel A Butt, Mariana Gerschenson, Matthew Bidwell Goetz, Margaret Doyle and 6 more
Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Suman KunduVanderbilt University Medical Center, Nashville, Tennessee, USA.
David C SamuelsVanderbilt University School of Medicine, Nashville, Tennessee, USA.
Samuel BailinVanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-4990-1013
Ke XuYale University Schools of Medicine and Public Health, West Haven, Connecticut, USA.
Kaku So-ArmahBoston University School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0003-1505-6384
Adeel A ButtWeill Cornell Medical College, New York, New York, USA.
Mariana GerschensonJohn A. Burns School of Medicine, University of Hawaii-Manoa, Honolulu, Hawaii, USA.
Matthew Bidwell GoetzVeterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA.
Margaret DoyleLerner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Russell TracyLerner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Vincent C MarconiEmory University School of Medicine, Rollins School of Public Health, Atlanta, Georgia, USA.
Amy JusticeYale University Schools of Medicine and Public Health, West Haven, Connecticut, USA.ORCID 0000-0003-0139-5502
Matthew FreibergVanderbilt University Medical Center, Nashville, Tennessee, USA.
John R KoetheVanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-6490-6942
Todd HulganVanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-3339-067X
Funding
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
The Role of gp120 on Cardiovascular Disease in People Living with HIVU54MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI Benjamin C. Fogelgren · 2017 to 2026
$59.5M
Tennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John Koethe · 2015 to 2026
$27.5M
TRPA1 Physiology in Diabetes, Metabolic Syndrome, and MetabolismP20GM113134 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI MARIANA GERSCHENSON · 2017 to 2026
$21.5M
Alcohol Associated Outcomes Among HIV+/- Aging VeteransU10AA013566 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2006 to 2010
$12.7M
Alcohol and Multisubstance Use in the Veterans Aging Cohort StudyU01AA020790 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$7.7M
The HIV and Alcohol Research center focused on Polypharmacy (HARP)P01AA029545 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2021 to 2025
$6.3M
Cardiovascular Disease Mechanisms in HIV Infected and Uninfected VeteransR01HL095136 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREIBERG, MATTHEW S, JUSTICE, AMY CAROLINE · 2008 to 2012
$5.6M
Sex Disparities in Overall Response to ART Among HIV Infected IndividualsU24AA020794 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$5.5M
Translational Research on Alcohol, Immunodeficiency, and Aging In COMpAAASU24AA022001 · NIAAA · YALE UNIVERSITY · PI BRANDT, CYNTHIA A. · 2012 to 2020
$3.2M
3/3 COMpAAAS Tripartite: ART-CC, KP, and VAU01AA026224 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2017 to 2021
$2.9M
Immune function and the risk of cvd among HIV infected and uninfected veteransR01HL125032 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FREIBERG, MATTHEW S, TRACY, RUSSELL P · 2014 to 2017
$2.8M
Emory Center for AIDS Research P20GM113134Emory Center for AIDS Research P30AI050409Emory Center for AIDS Research U54MD007601NHLBI NIH HHS R01 HL095136NHLBI NIH HHS R01 HL125032NHLBI NIH HHS R43 HL129586NHLBI NIH HHS R44 HL129586NIAAA NIH HHS P01 AA029545NIAAA NIH HHS U01 AA020790NIAAA NIH HHS U01 AA026224NIAAA NIH HHS U10 AA013566NIAAA NIH HHS U24 AA020794NIAAA NIH HHS U24 AA022001NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI110527NIDDK NIH HHS K23 DK135414NIGMS NIH HHS P20 GM113134NIH HHS P01 AA029545NIH HHS R01 HL095136NIH HHS R01 HL125032NIH HHS R01 HL129586)NIH HHS U01 AA020790NIH HHS U01 AA026224NIH HHS U10 AA013566NIH HHS U24 AA020794NIH HHS U24 AA022001NIMHD NIH HHS U54 MD007601
6 · The paper itself
Abstract
backgroundType 2 diabetes mellitus (DM) is common among people with human immunodeficiency virus (HIV). We previously reported that DM risk was greater in women of African ancestry with HIV who had mitochondrial DNA (mtDNA) haplogroup L3. We examined haplogroup associations with DM and selected soluble and cellular immune biomarkers among people with HIV (PWH) and those without HIV in the Veterans Aging Cohort Study (VACS) Biomarker Cohort.
methodsVACS participants had mtDNA haplogroups determined from genome-wide genotyping and adjudicated DM outcomes. Serum interleukin 6, D-dimer, and soluble CD14 were quantified, and cellular phenotyping was performed by flow cytometry, on blood collected during 2005-2007. Analyses included logistic and Cox regression of prevalent and incident DM, stratified by self-reported ancestry and HIV status, and adjusted for selected covariates.
resultsmtDNA haplogroups, soluble and/or cellular biomarkers, and DM outcomes were available for 2019 participants (65% with HIV; 68% non-Hispanic Black; 95% male). Among 781 Black PWH, mtDNA haplogroup L3 (40%) was associated with incident DM (hazard ratio, 1.56 [95% confidence interval, 1.01-2.40]) adjusting for covariates including senescent (CD28-) CD4+ T cells, which were lower in Black PWH having haplogroup L3 versus other African haplogroups (P = .05). No other haplogroups were associated with DM. There were no significant associations observed in Veterans without HIV, although the effect size was similar.
conclusionsmtDNA haplogroup L3 was associated with incident DM in predominantly male non-Hispanic Black PWH, replicating an association reported previously. This haplogroup was associated with fewer senescent CD4+ T cells, but the association with DM was independent of T-cell phenotype.
Indexed as
Diabetes Mellitus, Type 2DNA, MitochondrialHaplotypesHIV InfectionsInflammationVeteransAgedBiomarkersBlack or African AmericanCohort StudiesFemaleHumansMaleMiddle AgedRisk FactorsWhiteBiomarkersDNA, MitochondrialHIVlymphocytesmitochondrial DNAtype 2 diabetes mellitus
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Mitochondrial DNA Haplogroups, Biomarkers of Inflammation and Immune Activation, and Risk of Diabetes in Veterans With and Without Human Immunodeficiency Virus. · full record | Socratic