Evidence map›Paper›PMID 40488380›Full record

ReviewCytoskeleton (Hoboken, N.J.)2026

ARC Expands the DAAM1 Microexon-Mediated Actin-RHOA/ROCK Interplay.

Patryk Poliński, Marta Miret Cuesta, Manuel Irimia

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cytoskeleton (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Patryk PolińskiEuropean Molecular Biology Laboratory, EMBL Barcelona, Barcelona, Spain.ORCID https://orcid.org/0000-0002-1733-7983
Marta Miret CuestaDepartment of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra, Barcelona, Spain.
Manuel IrimiaDepartment of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra, Barcelona, Spain.ORCID https://orcid.org/0000-0002-2179-2567

Funding

European Research Council
6 · The paper itself

Abstract

Actin cytoskeleton and its dynamics play a crucial role in synaptic function, influencing dendritic spines' structural and functional plasticity. Recent findings unveiled the significance of alternative splicing of a neural-specific microexon in DAAM1 in modulating actin's role in synaptic processes. This article discusses the impact of this microexon on actin polymerization, the RHOA/ROCK signaling pathway, and cognitive functions. Furthermore, we present new results that reveal a more complex scenario involving the upregulation of the activity-regulated cytoskeleton-associated protein (ARC) protein in DAAM1 microexon KO models, which may further affect synaptic function and cognition.

Indexed as

ActinsCytoskeletal ProteinsExonsMicrofilament ProteinsNerve Tissue ProteinsrhoA GTP-Binding Proteinrho-Associated KinasesAnimalsHumansSignal TransductionActinsactivity regulated cytoskeletal-associated proteinCytoskeletal ProteinsMicrofilament ProteinsNerve Tissue ProteinsrhoA GTP-Binding Proteinrho-Associated Kinasesalternative splicingARCforminsynapse

Identifiers

PMID40488380
PMCPMC12993246

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.