Evidence map›Paper›PMID 40488445›Full record

ArticleeLife2025

Heterozygosity for neurodevelopmental disorder-associated

Yevheniia Ishchenko, Amanda T Jeng, Shufang Feng, Timothy Nottoli, Cindy Manriquez-Rodriguez, Khanh K Nguyen, Melissa G Carrizales, Matthew J Vitarelli, Ellen E Corcoran, Charles A Greer and 2 more

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Rho signaling promotes cell excitability and synaptic transmission.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Yevheniia Ishchenko *Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, United States.ORCID https://orcid.org/0000-0002-8631-9586
Amanda T Jeng *Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, United States.
Shufang FengDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, United States.
Timothy NottoliDepartment of Comparative Medicine, Yale School of Medicine, New Haven, United States.
Cindy Manriquez-RodriguezLaboratory for Immunochemical Circuits, La Jolla Institute for Immunology, La Jolla, United States.
Khanh K NguyenLaboratory for Immunochemical Circuits, La Jolla Institute for Immunology, La Jolla, United States.
Melissa G CarrizalesDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, United States.
Matthew J VitarelliDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, United States.
Ellen E CorcoranDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, United States.
Charles A GreerDepartment of Neuroscience, Yale School of Medicine, New Haven, United States.
Samuel A MyersLaboratory for Immunochemical Circuits, La Jolla Institute for Immunology, La Jolla, United States.
Anthony J KoleskeDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, United States.ORCID https://orcid.org/0000-0003-4105-9909

Funding

Dysregulation of TRIO GEF1 activity in neurodevelopmental disordersR01MH133562 · NIMH · YALE UNIVERSITY · PI Anthony J Koleske · 2023 to 2026
$3.4M
Identification and characterization of chemical probes of TRIO GEF1 activityR01MH132685 · NIMH · YALE UNIVERSITY · PI Anthony J Koleske · 2024 to 2026
$1.7M
The role of TRIO signaling in neuronal development, synaptic function, and circuit connectivityR56MH122449 · NIMH · YALE UNIVERSITY · PI CARDIN, JESSICA A, HIGLEY, MICHAEL JAMES · 2021 to 2022
$1.4M
American Heart Association 20POST35210428NIH HHS R01MH132685NIH HHS R01MH133562NIH HHS R56MH122449NIMH NIH HHS R01 MH132685NIMH NIH HHS R01 MH133562NIMH NIH HHS R56 MH122449Simons Foundation Pilot Award
6 · The paper itself

Abstract

Genetic variants in

Indexed as

Behavior, AnimalGuanine Nucleotide Exchange FactorsHeterozygoteNeurodevelopmental DisordersSynaptic TransmissionAnimalsDisease Models, AnimalFemaleHumansMaleMiceNeuronsGuanine Nucleotide Exchange FactorsmouseNeurodevelopmental disordersneurosciencepresynapticRac1RhoATRIO

Identifiers

PMID40488445
PMCPMC12148328

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.