ArticleAnalytical chemistry2025
Development of a Thiol-ene Microfluidic Chip for Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS).
Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Probing protein-lipid interactions by hydrogen/deuterium exchange-mass spectrometry: advances, challenges and future directions.Chemical science · 2026Review
- Article
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Authors and funding
9 authors.
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Abstract
Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is a powerful technique for analyzing the conformational dynamics of proteins. Using liquid chromatography coupled to mass spectrometry (LC-MS), the method achieves high sensitivity and the option to measure the HDX either of the intact protein (global analysis) or of small peptide segments of the protein (local analysis) after online pepsin proteolysis. However, HDX-MS is currently limited by the significant cost of the specialized refrigerated UPLC-based chromatographic equipment needed and by the loss of deuterium label from the analyzed protein (30-50%), which still occurs despite cooling parts of the LC-MS system to 0 °C. Here we describe the development of a microfluidic chip (
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