Trial reportEuropean journal of pediatrics2025
What about the heart - pediatric ALL survivors show cardiopulmonary limitations in the MinimALL Study.
Trial report in European journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06093334 (iMagINg of Chemotherapy-Induced Morphological and Functional Lung Changes in Childhood Acute Lymphoblastic Leukemia and Hodgkin's Disease), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
iMagINg of Chemotherapy-Induced Morphological and Functional Lung Changes in Childhood Acute Lymphoblastic Leukemia and Hodgkin's Disease
Who cites it
2 citing papers in PubMed.
- The cardiovascular future of childhood cancer survivors: are we ready?European journal of pediatrics · 2026Article
- Cardiovascular Care in Pediatric Cancer Survivors: Updates on Risk, Prevention, and Therapies.Current treatment options in oncology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Childhood survivors of acute lymphoblastic leukemia (ALL) and Hodgkin disease (HD) are at risk of long-term cardiopulmonary impairments due to cardiotoxic chemotherapy and inactivity. This study aims to assess the cardiopulmonary fitness and cardiac function of pediatric cancer survivors (PCS) using cardiopulmonary exercise testing (CPET) and echocardiography, including strain imaging, to determine the extent of functional limitations and their underlying causes. This prospective, single-center study included 27 PCS (21 with ALL, 6 with HD) and 27 age-matched healthy controls. Participants underwent echocardiography with strain analysis and CPET on a treadmill to evaluate cardiac function and exercise capacity. Key parameters such as ejection fraction (EF), global longitudinal strain (GLS), E/E' ratio, peak oxygen uptake (
conclusionOur study underscores the importance of diastolic assessments and advanced echocardiographic techniques in monitoring PCS, with E/E' septal emerging as a key marker. CPET provides valuable insights into the functional impact of early cardiac changes. Despite signs of diastolic dysfunction at rest, stroke volume and pulmonary function were preserved during exercise, suggesting that detraining may partly contribute to reduced TRAIL REGISTRATION: NCT06093334. WHAT IS KNOWN: • Childhood survivors of ALL and HD are at risk of long-term cardiopulmonary impairments due to chemotherapy-related cardiotoxicity and reduced physical activity. • CPET and echocardiography, including strain imaging, are valuable tools for assessing cardiac function and exercise capacity in this population. WHAT IS NEW: • Early diastolic dysfunction detected: despite normal EF and GLS, PCS exhibit an elevated E/E' septal ratio, reinforcing its role as a key marker for early cardiac changes.• Reduced exercise capacity linked to detraining: PCS show significantly lower
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.