ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2025
MYC: The Guardian of Its Own Chaos.
Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Role of Myc in the Realization of the Growth Potential of Different Types of Neural Progenitor Cells and the Secretory Function of Neuroglial Cells.Bulletin of experimental biology and medicine · 2026Article
- A Darwinian Perspective on Tumor Evolution.International journal of biological sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
MYC proteins are potent oncoproteins that drive tumorigenesis in a wide range of cancers, making it critical to understand their oncogenic functions and underlying mechanisms. Although MYC overexpression induces transcriptional and replication-associated stress, recent studies have paradoxically identified MYC as a key resilience factor that protects cancer cells from these stressors. In this review, we explore the dual role of MYC in both driving and mitigating cellular stress to achieve its oncogenic function. We also examine how MYC-induced transcriptional and replicative stress generates potentially immunogenic nucleic acid species while simultaneously helping cancer cells evade host immune recognition. We propose a model in which MYC plays a critical role in managing the stress it induces, thereby maintaining a balance that promotes tumor growth. Based on this model, we discuss potential therapeutic strategies targeting MYC-dependent stress responses, offering new avenues for cancer treatment and highlighting the complexity of MYC-driven oncogenesis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.