Evidence mapPaperPMID 40489227Full record

ArticleChannels (Austin, Tex.)2025

Structural and functional mapping of ion access pathways in the human K

Robert T Szerencsei, Shitian Cai, Hristina R Zhekova, Ali H Jalloul, D Peter Tieleman, Paul P M Schnetkamp

Abstract read
In one paragraph

Article in Channels (Austin, Tex.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Robert T SzerencseiDepartment of Physiology & Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Shitian CaiDepartment of Physiology & Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Hristina R ZhekovaCentre for Molecular Simulation, Department of Biological Sciences, University of Calgary, Calgary, Canada.
Ali H JalloulDepartment of Physiology & Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada.
D Peter TielemanCentre for Molecular Simulation, Department of Biological Sciences, University of Calgary, Calgary, Canada.
Paul P M SchnetkampDepartment of Physiology & Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

K

Indexed as

CysteineSodium-Calcium ExchangerHEK293 CellsHumansMesylatesMolecular Dynamics SimulationMutagenesisSulfhydryl ReagentsCysteineMesylatespotassium-dependent sodium-calcium exchangerSodium-Calcium ExchangerSulfhydryl Reagentshomology modelingion access pathwaysK+-dependent Na+/Ca2+ exchangersmolecular dynamicsNCKX2

Identifiers

PMID40489227
PMCPMC12150658

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.