Observational studyMedicine2025
Gender differences in aortic blood pressure, arterial stiffness, and cerebral blood flow in healthy adults: A STROBE-compliant cross-sectional observational study.
Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Letter regarding "Reduced Fistula Patency in Female Mice".JVS-vascular science · 2026Article
- Association of BMI Grading with Aortic Pulse Wave Velocity and Augmentation Index in a Population of West India.Nigerian medical journal : journal of the Nigeria Medical AssociationReview
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding gender-specific differences due to anatomical and physiological variations in cardiovascular and cerebrovascular physiology is essential. Thus, this study explores variations in aortic and blood pressure, arterial stiffness, and cerebral blood flow between healthy men and women. The study involved 36 healthy participants (23 males and 13 females). Aortic blood pressure (aBP) and arterial stiffness were assessed using pulse wave analysis and pulse wave velocity, respectively, via Vicorder® software. Cerebral blood flow in the middle cerebral artery, internal carotid artery (ICA), and common carotid artery (CCA) was evaluated using high-resolution ultrasound, with automated edge-detection software used for ICA and CCA diameter measurements. Males showed significantly higher aBP and arterial stiffness compared to females (systolic aBP mean difference [MD] + 15.74 mm Hg, P < .001; diastolic aBP MD + 6.57 mm Hg, P = .01; arterial stiffness MD + 1.01 m/s, P < .001). In contrast, CCA peak systolic velocity (CCA-PSV) was significantly higher (MD + 0.20 m/s, P = .001) in males compared to females, with no significant differences were observed in middle cerebral artery-PSV (P = .10) nor ICA-PSV (P = .99). Males also had a larger CCA diameter (MD + 0.45 mm, P = .01) and ICA diameter (MD + 0.41 mm, P = .05). The findings of this study showed significant gender differences in aBP, arterial stiffness, and characteristics of the extracranial arteries. The observed of higher central BP and arterial stiffness, along with elevated CCA peak systolic velocity and larger CCA and ICA diameters combination in healthy males, suggests a compensatory mechanism that may help preserve cerebral perfusion in the presence of increased blood pressure and arterial stiffness. These highlight the importance of considering gender-specific cardiovascular and cerebrovascular responses in clinical assessments and interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.