Observational studyMedicine2025
Effect of glucocorticoid combined with azithromycin on serum inflammatory factors and pulmonary function in children with influenza A virus-induced pneumonia.
Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Systemic Corticosteroids in Pediatric Community-Acquired Pneumonia: Evidence, Clinical Outcomes, and Phenotype-Based Therapeutic Considerations.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Effects of high-dose intravenous immunoglobulin on efficacy, inflammatory markers, and pulmonary function in adults with severe acute viral pneumonia.American journal of translational research · 2026Article
- Clinical characteristics, tongue manifestations, and traditional Chinese medicine syndrome patterns of spring influenza A in children: a single-center retrospective study.Frontiers in pediatrics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Influenza A virus pneumonia in children is a serious respiratory infection disease. In view of the limitations of single treatment at present, this study aims to explore the clinical effect of glucocorticoid (GC) combined with azithromycin (AZM) on it. the data of 75 children with swine flu pneumonia were analyzed retrospectively, and they were divided into GC group (GCG), AZM group (AZMG), and GC + AZM group (combined group, CG) according to the treatment scheme, with 25 cases in each group. Clinical symptom recovery time, total effective rate, pulmonary function index before and after the treatment, including peak expiratory flow (PEF), forced vital capacity (FVC), functional residual capacity (FRC), maximum inspiratory pressure (PImax), and other pulmonary ventilation indicators, and serum inflammatory factors such as interleukin-8 (IL-8), interleukin-8 (IL-6), tumor necrosis factor-α (TNF-α), c-reactive protein (CRP), white blood cell (WBC), and procalcitonin (PCT) were compared. the recovery time of body temperature and disappearance time of lung rales in the CG group were significantly shorter than those in the GCG/AZMG group (P < .05), with a total effective rate of 92%, which was significantly higher than that in the GCG/AZMG group (60%, 64%, P < .05). The lung function index and serum inflammatory factors were significantly improved, PEF, FVC, FRC, and PImax were significantly increased, while TNF-α, IL-8, IL-6, CRP, WBC, and PCT were significantly decreased in CG compared with GCG and AZMG (P < .05). There was no significant difference in the incidence of adverse reactions (rash events, nausea and vomiting, diarrhea) among the 3 groups (P > .05). the combined use of GC and AZM shows better efficacy than single treatment in treating children with influenza A virus pneumonia, which can significantly shorten the recovery time of clinical symptoms, improve the treatment efficiency, improve lung function indexes and reduce the level of serum inflammatory factors. This discovery provides a new idea for the clinical treatment of children with swine flu pneumonia.
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