ArticleThe Journal of nutrition2025
A Genome-Wide Association Study of Taste Liking in the Danish Population.
Article in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Taste Modulation by Umami Compounds: Mechanisms, Sensor-Based Evaluation, and Pharmaceutical Applications in Bitterness Suppression.Sensors (Basel, Switzerland) · 2026Review
- Genetic Variants Influencing Taste Perception and Food Preferences: Current Evidence.Nutrients · 2026Review
- Exploratory Genome-Wide Association Study of Grapefruit Intake and Its Potential Link to Obesity Risk in US Cohorts.Nutrients · 2026Article
- The Emerging Role of Olfactory Receptors: From Genomics to Precision Medicine.Molecular diagnosis & therapy · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTaste liking, a complex trait, plays an important role in food choice and eating behavior, thereby influencing risk of diet-related diseases.
objectivesThis study aimed to identify novel loci that could explain differences in liking of 5 basic tastes, fat sensation, and 2 oral sensations, represented by several food items.
methodsLiking scores were derived using a newly developed taste liking questionnaire (TasteLQ), validated in the Danish population. We conducted a genome-wide association study (GWAS) of liking of 6 modalities (sweet, salty, sour, bitter-astringency, umami, and pungency) and 9 factors representing modality subgroups among 6,437 Danish adults. As a secondary analysis, GWASs of 44 single food items from TasteLQ were also undertaken.
resultsWe identified 1 genome-wide significant variant, rs170518 (minor allele frequency = 0.16), on chromosome 5, associated with liking of an umami factor characterized by glutamate-rich food items [P = 3.7 × 10
conclusionsAlthough our findings provide insight into loci involved in taste liking, they remain preliminary and warrant additional validation due to lack of replication in an independent population and limited number of genome-wide significant associations.
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