Evidence map›Paper›PMID 40490646›Full record

ArticleGeroScience2026

Retinal vessel diameter reflects altered resting-state fMRI connectivity and cognitive performance: A community-based study.

Yan Min, Chang Liu, Yanli Zhang, Yuesong Pan, Tao Liu, Hongyu Zhou, Zixiao Li, Yongjun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yan MinDepartment of Neurology, Beijing TianTan Hospital, Capital Medical University, Beijing, China.
Chang LiuBeijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Yanli ZhangDepartment of Neurology, Beijing TianTan Hospital, Capital Medical University, Beijing, China.
Yuesong PanDepartment of Neurology, Beijing TianTan Hospital, Capital Medical University, Beijing, China.
Tao LiuBeijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Hongyu ZhouDepartment of Neurology, Beijing TianTan Hospital, Capital Medical University, Beijing, China.
Zixiao LiDepartment of Neurology, Beijing TianTan Hospital, Capital Medical University, Beijing, China. lizixiao2008@hotmail.com.
Yongjun WangDepartment of Neurology, Beijing TianTan Hospital, Capital Medical University, Beijing, China. yongjunwang@ncrcnd.org.cn.

Funding

Beijing Natural Science Foundation Z200016National Key R&D Programme of China 2022YFC2504900National Key R&D Programme of China 2022YFC2504902
6 · The paper itself

Abstract

This study investigated the relationship between fundus microvascular characteristics and the nodal local efficiency (Nle) of brain functional connectivity (FC), as well as their association with cognitive performance in a community-based cohort. A total of 1532 participants from Lishui City, China, were enrolled between May 2017 and September 2019 as part of the polyvascular evaluation for cognitive impairment and vascular events (PRECISE) study. Cognitive performance was assessed using the Montreal Cognitive Assessment-Beijing (MoCA-Beijing), and Nle was derived from resting-state functional magnetic resonance imaging (rs-fMRI). Fundus photography of the left eye was performed to measure microvascular features, including the central retinal arterial equivalent (CRAE), central retinal vein equivalent (CRVE), and their ratio (AVR). Correlations between fundus microvascular indices, cognitive function scores, and brain FC were analyzed. Notably, a wider CRVE was significantly associated with poorer naming scores on cognitive assessments. Several key brain regions, including the left orbital gyrus, right inferior temporal gyrus, left parahippocampal gyrus, bilateral posterior hippocampus, left fusiform gyrus, and left inferior parietal lobule, demonstrated significant correlations between fundus microvascular indices and brain FC. These regions played a crucial role in cognitive function and neural network connectivity. Overall, fundus microvascular characteristics were correlated with the indicators of brain FC related to cognitive function. Our findings suggest that fundus microvascular characteristics may serve as a potential non-invasive biomarker for detecting brain functional alterations linked to cognitive dysfunction in elderly populations.

Indexed as

BrainCognitionCognitive DysfunctionMagnetic Resonance ImagingRetinal VesselsAgedChinaFemaleHumansMaleMiddle AgedCognitive functionFunctional connectivityFundus microvascular characteristicsResting state functional magnetic resonance imaging (rs-fMRI)

Identifiers

PMID40490646
PMCPMC12972180

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.