ArticleEuropean journal of medical research2025
B7-H3 and c-MET in advanced prostate cancer: exploring possibilities of novel bi-specific drug development.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- MET-associated immune prognostic signature predicts survival and guides personalized therapy in glioma.Acta neuropathologica communications · 2026Article
- Fibroblast-mediated KRAS activation in double-negative prostate cancer.Cell death & disease · 2026Article
- A novel cytotoxic anti-B7-H3 affibody with therapeutic potential in acute myeloid leukemia.Frontiers in pharmacology · 2025Article
- Breaking the cancer code: a novel DNA minicircle to disable STAT3 in ovarian cancer cells SKOV3.Frontiers in pharmacology · 2025Article
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12 authors.
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Abstract
purposeProstate cancer (PCa) is a serious malignancy worldwide with the fifth highest mortality rate among tumors in males, and there are unmet clinical needs for PCa treatment. In this work, we aim to explore the expression and overlap between B7 Homolog 3 protein (B7-H3) and cell-surface receptor c-mesenchymal-epithelial transition factor (c-MET), to provide insight on B7-H3 and c-MET bi-specific ADC drugs development for advanced PCa. PATIENTS AND
methodsIn this retrospective cross-sectional study, formalin-fixed paraffin-embedded (FFPE) samples were analyzed from 135 male patients with advanced PCa at Hubei Cancer Hospital between 2019 and 2023. Biomarker and drug information were collected and used as major factors for patient stratification. Protein expression of B7-H3 (D9M2L) and c-MET (SP44) were determined by staining intensity and percent staining measurements. Positive expression of B7-H3 was defined as H Score ≥100, and positive expression of c-MET was defined as H Score >0. Historical medical information related to these cases were collected and the data were analyzed by R.
results44% samples had both positive B7-H3 expression and c-MET expression, but c-MET expression is higher in peri-tumor sites than it in tumor site in PCa. The expression of B7-H3 and c-MET did not demonstrate significant correlation with age, metastatic site, or disease control rate (DCR). In addition, progression-free survival (PFS) of B7-H3 negative c-MET positive group was significantly shorter compared to the rest groups in patients receiving androgen deprivation therapy (ADT), while the expression of two markers was not significantly correlated with PFS in patients receiving ADT and new androgen receptor (AR) antagonists.
conclusionsIn conclusion, B7-H3 is a promising drug developing target for PCa; however, c-MET may be limited by its low expression in tumor site while relative higher expression in peri-tumor site in PCa. Further investigation is warranted regarding bi-specific drugs for B7-H3 and another marker.
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