ArticleCNS neuroscience & therapeutics2025
Free Water-Corrected Fractional Anisotropy in Normal-Appearing White Matter as a Potential Neuroimaging Biomarker for Attention and Executive Function Impairment in Cerebral Small Vessel Disease.
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Diabetes, hyperglycemia, and brain MRI biomarkers: results from SOL-INCA MRI study.Nutrition & diabetes · 2026Article
- Perivascular diffusion and white matter free water improve identification of cognitive impairment in cerebral small vessel disease.Frontiers in neurology · 2026Article
- White and gray matter diffusion-derived differences in type 2 diabetes mellitus: a free-water-corrected diffusion MRI study.Frontiers in medicine · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveTo investigate the relationship between white matter integrity changes and attention/executive function in cerebral small vessel disease (CSVD), focusing on tract-specific alterations over stages and identifying key neuroimaging markers affecting cognitive decline.
methodsA total of 170 CSVD patients, including 103 Vascular Cognitive Impairment (VaMCI) and 67 with no cognitive impairment (NCI) underwent MRI and neuropsychological assessments. Neuroimaging metrics included quantitative susceptibility (QS), free water (FW), FW-corrected fractional anisotropy (FAt) and FW-corrected mean diffusivity (MDt) in white matter hyperintensities (WMH) and normal-appearing white matter (NAWM). WMH volume, gray/white matter volume, lacunar infarcts (LI) volume and counts were also included. Partial correlations were conducted to assess neuroimaging-cognition relationships, and random forest analysis was employed to determine the relative importance of these indices, with a particular focus on white matter tracts.
resultsThe VaMCI group exhibited decreased NAWM FAt and white matter volume, increased NAWM QS, WMH volume, LI volume and counts when compared to the NCI group. NAWM/WMH FAt positively associated with attention/executive function, whereas NAWM/WMH QS, FW, MDt, WMH volume, and LI metrics negatively correlated. Notably, NAWM FAt was the most significant variable, especially in frontal white matter tracts and thalamic radiation.
conclusionNAWM FAt significantly impacts attention/executive function in CSVD, particularly in the frontal lobe and thalamic radiation, and may serve as an early potential neuroimaging biomarker for cognitive decline.
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