Evidence map›Paper›PMID 40491362›Full record

ArticleAging cell2025

Brain DNA Methylation Age, Lifestyle Factors and Dementia in the Swedish Twin Registry.

Christopher E McMurran, Ida K Karlsson, Shayan Mostafaei, Yunzhang Wang, Lotte Gerritsen, Nancy L Pedersen, Sara Hägg

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christopher E McMurranDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE, Sweden.ORCID 0000-0002-8710-0930
Ida K KarlssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE, Sweden.ORCID 0000-0003-3605-7829
Shayan MostafaeiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE, Sweden.ORCID 0000-0002-1966-1306
Yunzhang WangDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE, Sweden.ORCID 0000-0003-1165-3595
Lotte GerritsenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE, Sweden.ORCID 0000-0002-8990-5396
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE, Sweden.ORCID 0000-0001-8057-3543
Sara HäggDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE, Sweden.ORCID 0000-0002-2452-1500

Funding

GENETIC &ENVIRONMENTAL INFLUENCES--BIOBEHAVIORAL AGINGR01AG010175 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 1992 to 2006
$2.8M
DEMENTIA IN TWINSR01AG008724 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET · 1990 to 2002
$1.4M
Repurposing drugs for Alzheimer´s disease using a reverse translational approachR01AG067996 · NIA · KAROLINSKA INSTITUTE · PI HAGG, SARA · 2024 to 2025
$973k
Forskningsrådet för Arbetsliv och Socialvetenskap 2009-0795Forskningsrådet för Arbetsliv och Socialvetenskap 97:0147:1BKarolinska Institutet FoundationKnut och Alice Wallenbergs StiftelseMacArthur Foundation Research Network on Successful AgingNational Institute for Health and Care ResearchNIA NIH HHS 1R01AG067996-01A1NIA NIH HHS R01 AG008724NIA NIH HHS R01 AG010175NIA NIH HHS R01 AG067996NIH HHS AG04563NIH HHS AG08724NIH HHS AG10175The Alzheimer's Association ZEN-02-3895Vetenskapsrådet 2017-00641Vetenskapsrådet 2020-06101Vetenskapsrådet 2022-01608Vetenskapsrådet 521-2013-8689Vetenskapsrådet 825-2007-7460Vetenskapsrådet 825-2009-6141
6 · The paper itself

Abstract

Advanced age is the most important risk factor for dementia. Measures of biological ageing such as DNA methylation age (DNAmAge) can give more information about the accumulation of age-related molecular damage in different organs than chronological age alone. Using post-mortem brain tissue from Swedish Twin Registry participants, we explored the relationship between lifestyle factors, dementia and DNAmAge measures from prefrontal cortex and cerebellum (n = 27 individuals) and paired blood samples (n = 20 individuals). We observed that smoking was associated with a higher DNAmAge deviation (PCBrainAge + 6.4 years in prefrontal cortex, CI [2.5, 10.3], p = 0.004). Conversely, a longer time spent in formal education was associated with a lower DNAmAge deviation (DNAmClock

Indexed as

AgingBrainDementiaDNA MethylationLife StyleAgedAged, 80 and overFemaleHumansMaleMiddle AgedRegistriesSwedenageingbraincerebellumdementiaDNA methylationlifestyleprefrontal cortexregistries

Identifiers

PMID40491362
PMCPMC12341783

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.