Evidence map›Paper›PMID 40491478›Full record

ArticleiScience2025

Mapping protein-metabolite interactions in

Mateusz Wagner, Jieun Kang, Catherine Mercado, Venkatesh P Thirumlaikumar, Michal Gorka, Hanne Zillmer, Jingzhe Guo, Romina I Minen, Caroline F Plecki, Katayoon Dehesh and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mateusz WagnerBoyce Thompson Institute, Ithaca, NY 14853, USA.
Jieun KangBoyce Thompson Institute, Ithaca, NY 14853, USA.
Catherine MercadoBoyce Thompson Institute, Ithaca, NY 14853, USA.
Venkatesh P ThirumlaikumarBoyce Thompson Institute, Ithaca, NY 14853, USA.
Michal GorkaCelon Pharma, 05092 Lomianki, Poland.
Hanne ZillmerMax-Planck-Institute of Molecular Plant Physiology, 14476 Potsdam-Golm, Germany.
Jingzhe GuoUniversity of California, Riverside, Riverside, CA 92521, USA.
Romina I MinenBoyce Thompson Institute, Ithaca, NY 14853, USA.
Caroline F PleckiBoyce Thompson Institute, Ithaca, NY 14853, USA.
Katayoon DeheshUniversity of California, Riverside, Riverside, CA 92521, USA.
Frank C SchroederBoyce Thompson Institute, Ithaca, NY 14853, USA.
Dirk WaltherMax-Planck-Institute of Molecular Plant Physiology, 14476 Potsdam-Golm, Germany.
Aleksandra SkiryczBoyce Thompson Institute, Ithaca, NY 14853, USA.

Funding

Small molecule signaling in C. elegansR35GM131877 · NIGMS · BOYCE THOMPSON INST FOR PLANT RESEARCH · PI Frank Clemens Schroeder · 2019 to 2026
$5.0M
NIGMS NIH HHS R35 GM131877
6 · The paper itself

Abstract

Toward characterization of protein-metabolite interactomes, we recently introduced PROMIS, a co-fractionation-based mass spectrometry approach. However, the challenge lies in distinguishing true interactors from coincidental co-elution when a metabolite co-fractionates with numerous proteins. To address this, we integrated two chromatographic techniques-size exclusion and ion exchange-to enhance the mapping of protein-metabolite interactions (PMIs) in

Indexed as

MetabolomicsMicrobiologyOmics

Identifiers

PMID40491478
PMCPMC12148380

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.