Evidence map›Paper›PMID 40491491›Full record

ArticleiScience2025

Growth of human regulatory CD4

Alejandro Moro, Aixin Yu, Luis Nivelo, Zhen Gao, Yuguang Ban, Alejandro V Villarino, Thomas R Malek

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alejandro MoroDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Aixin YuDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Luis NiveloDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Zhen GaoSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Yuguang BanSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Alejandro V VillarinoDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Thomas R MalekDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

Funding

Tumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Stephen D. Nimer · 2019 to 2026
$24.1M
Low dose IL-2 and human regulatory T cellsR01AI131648 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MALEK, THOMAS R · 2018 to 2022
$3.0M
NCI NIH HHS P30 CA240139NIAID NIH HHS R01 AI131648
6 · The paper itself

Abstract

Foreign and self-antigens activate CD4

Indexed as

Components of the immune systemImmunology

Identifiers

PMID40491491
PMCPMC12148606

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.