ArticleInternational journal of nanomedicine2025
Altered Neuroplasticity in Epilepsy is Associated with Neuroinflammation and Oxidative Stress: In vivo Evidence of Brain-Derived Extracellular Vesicles.
Article in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A Novel Reporter Mouse for Astrocyte-Derived Extracellular Vesicles Reveals Enrichment of Cargo at Neuronal Mitochondria.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Green-synthesizedRSC advances · 2026Article
- A novel reporter mouse for astrocyte-derived extracellular vesicles reveals trafficking of cargo to neuronal mitochondria.bioRxiv : the preprint server for biology · 2026Article
- Normalization strategies for protein quantification in plasma astrocyte-derived extracellular vesicles: a clinical applicability study.BMC psychiatry · 2026Article
- Microfluidic nanomagnetically isolated neuron- and astrocyte-derived extracellular vesicles to differentiate Lewy body and Alzheimer's disease.Npj biosensing · 2026Article
- Nanomaterials Covered with Cell Membranes for Intracellular Delivery Without Lysosomal Degradation and Innate Immunity Induction.International journal of molecular sciences · 2025Article
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5 authors.
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Abstract
Purpose: Recurrent seizures lead to self-reconstruction of the central nervous system, which is termed the neuroplasticity of epilepsy. While preclinical studies implicate neuroinflammation and oxidative stress in epilepsy-associated neuroplasticity, in vivo molecular-level evidence in humans is lacking. Patients and Methods: We used astrocyte-derived extracellular vesicles (ADEVs) and neuron-derived extracellular vesicles (NDEVs) as brain-derived biomarkers to explore biomarkers of neuroplasticity, neuroinflammation, and oxidative stress. A total of 50 patients in the epilepsy group (EP) and 25 matched healthy controls (HC) were recruited for this study. Plasma ADEVs and NDEVs were isolated and confirmed, and the levels of the EV marker CD81, the neuroplasticity marker brain-derived neurotrophic factor (BDNF), and the neuroinflammation marker tumor necrosis factor α (TNF-α) in ADEVs, as well as the markers of oxidative stress, superoxide dismutase 1 (SOD1) and malondialdehyde (MDA), in NDEVs were measured. Results: BDNF levels in ADEVs and SOD1 levels in NDEVs from EP were significantly lower than those in HC, whereas TNF-α levels in ADEVs and MDA levels in NDEVs were significantly increased, and the results remained stable after normalization by CD81. Spearman correlation analysis revealed that BDNF levels in ADEVs were negatively correlated with TNF-α levels in ADEVs and MDA levels in NDEVs and positively correlated with SOD1 levels in NDEVs. Conclusion: The innovative use of ADEVs and NDEVs as brain-derived biomarkers in this study provides in vivo evidence that epilepsy may result in impaired neuroplasticity and may be associated with increased neuroinflammation and oxidative stress.
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