Evidence map›Paper›PMID 40492897›Full record

ArticleAdvanced healthcare materials2025

Permeation Enhancer-based Ionogel Shows Remarkable Potential for Oral Insulin Delivery.

Konstantinos Raptis, Joanne Heade, Cristiana Cunha, Marco van de Weert, Lasse Saaby, Stine Rønholt, Hanne Mørck Nielsen

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Konstantinos RaptisDepartment of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, 2100, Denmark.ORCID https://orcid.org/0009-0000-5327-9875
Joanne HeadeDepartment of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, 2100, Denmark.ORCID https://orcid.org/0000-0001-8470-5144
Cristiana CunhaDepartment of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, 2100, Denmark.ORCID https://orcid.org/0000-0001-9143-6587
Marco van de WeertDepartment of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, 2100, Denmark.ORCID https://orcid.org/0000-0002-8530-6441
Lasse SaabyDepartment of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, 2100, Denmark.ORCID https://orcid.org/0000-0003-4271-8304
Stine RønholtDepartment of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, 2100, Denmark.ORCID https://orcid.org/0000-0001-9149-6061
Hanne Mørck NielsenDepartment of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, 2100, Denmark.ORCID https://orcid.org/0000-0002-7285-9100

Funding

Danmarks Grundforskningsfond DNRF122HORIZON EUROPE European Innovation Council FP/2007-2013Innovative Medicines Initiative Joint Undertaking FP7/2007-2013Lundbeck Foundation R155-2013-14113Novo Nordisk Fonden NNF16OC0021948Villum Fonden 19175Villum Fonden 9301
6 · The paper itself

Abstract

The increased focus on peptide therapeutics has created an unmet need for technologies and materials enabling therapeutic efficacy after oral administration. Currently, permeation enhancers are the gold standard for oral peptide delivery, with sodium decanoate being one of the most widely tested in preclinical and clinical studies. This study aims to develop and investigate a decanoate-based ionic liquid (IL) inspired by the reported absorption enhancing effect of choline geranate (CAGE) IL. The delivery system is prepared by loading choline decanoate with insulin and upon optimization of the ratio, the chC

Indexed as

Drug Delivery SystemsInsulinAdministration, OralAnimalsDecanoic AcidsGelsHumansIonic LiquidsMaleRatsViscositydecanoic acidDecanoic AcidsGelsInsulinIonic Liquidsdrug delivery systemin vivoionic liquidoral peptide deliverypermeation enhancer

Identifiers

PMID40492897
PMCPMC12333474

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.