Evidence map›Paper›PMID 40493189›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

CRISPR screens and quantitative proteomics reveal remodeling of the aryl hydrocarbon receptor-driven proteome through PARP7 activity.

Andrii Gorelik, Joao A Paulo, Christina B Schroeter, Melanie Lad, Abigail Shurr, Chara Mastrokalou, Samrah Siddiqi, Osamu Suyari, John Brognard, David Walter and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Functional genomic analysis of non-canonical DNA regulatory elements of the aryl hydrocarbon receptor.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Andrii GorelikSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom.ORCID 0000-0001-5354-4042
Joao A PauloDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-4291-413X
Christina B SchroeterDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-1391-7817
Melanie LadCancer Research Horizons, Joint AstraZeneca-Cancer Research Horizons Functional Genomics Centre, Cambridge CB2 0AW, United Kingdom.
Abigail ShurrCancer Research Horizons, Joint AstraZeneca-Cancer Research Horizons Functional Genomics Centre, Cambridge CB2 0AW, United Kingdom.
Chara MastrokalouCancer Research Horizons, Joint AstraZeneca-Cancer Research Horizons Functional Genomics Centre, Cambridge CB2 0AW, United Kingdom.
Samrah SiddiqiSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom.
Osamu SuyariSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom.
John BrognardLaboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702.ORCID 0000-0002-9243-6615
David WalterCancer Research Horizons, Joint AstraZeneca-Cancer Research Horizons Functional Genomics Centre, Cambridge CB2 0AW, United Kingdom.
Jason MatthewsDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo 0317, Norway.
Timothy M PalmerBiomedical Institute for Multimorbidity, Centre for Biomedicine, Hull York Medical School, University of Hull, Hull HU6 7RX, United Kingdom.ORCID 0000-0002-9803-7164
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115.
Ivan AhelSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom.ORCID 0000-0002-9446-3756

Funding

New Sample Multiplexing Technologies to Identify Chemical Probes and Illuminate Ubiquitin BiologyR01GM067945 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI GYGI, STEVEN P · 2003 to 2024
$10.5M
Advancing Multiplexed Isobaric Tag-based Strategies for Proteome ProfilingR01GM132129 · NIGMS · HARVARD MEDICAL SCHOOL · PI PAULO, JOAO A · 2019 to 2023
$1.7M
Cancer Research UK (CRUK) C35050/A22284HHS | NIH (NIH) GM132129HHS | NIH (NIH) GM67945NIGMS NIH HHS R01 GM067945NIGMS NIH HHS R01 GM132129UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/R007195/1 BB/W016613/1Wellcome TrustWellcome Trust (WT) 210634 223107 302632Wellcome Trust (WT) 224095/Z/21/Z
6 · The paper itself

Abstract

PARP7 is an enzyme that uses donor substrate NAD

Indexed as

Poly(ADP-ribose) PolymerasesProteomeReceptors, Aryl HydrocarbonBasic Helix-Loop-Helix ProteinsCell Line, TumorClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsHumansLung NeoplasmsNucleoside Transport ProteinsProteomicsSignal TransductionSuppressor of Cytokine Signaling 3 ProteinAHR protein, humanBasic Helix-Loop-Helix ProteinsNucleoside Transport ProteinsPoly(ADP-ribose) PolymerasesProteomeReceptors, Aryl HydrocarbonSOCS3 protein, humanSuppressor of Cytokine Signaling 3 ProteinTiPARP protein, humanADP-ribosylationaryl hydrocarbon receptorCRISPRPARPproteomics

Identifiers

PMID40493189
PMCPMC12184497

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.