Evidence map›Paper›PMID 40494344›Full record

ArticleCell genomics2025

Human genetic variation reveals FCRL3 is a lymphocyte receptor for Yersinia pestis.

Rachel M Keener, Sam Shi, Trisha Dalapati, Liuyang Wang, Nicolás M Reinoso-Vizcaino, Micah A Luftig, Samuel I Miller, Timothy J Wilson, Dennis C Ko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Anti-infective compounds forSustainable microbiology · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Rachel M KeenerDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA; University Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA.
Sam ShiDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA.
Trisha DalapatiDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA.
Liuyang WangDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA.
Nicolás M Reinoso-VizcainoDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA.
Micah A LuftigDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA.
Samuel I MillerDepartments of Genome Sciences, Medicine, and Microbiology, University of Washington, Seattle, WA 98195, USA.
Timothy J WilsonDepartment of Microbiology, Miami University, Oxford, OH 45056, USA.
Dennis C KoDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA; University Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA; Division of Infectious Diseases, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA. Electronic address: dennis.ko@duke.edu.

Funding

Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6M
HUMAN GENETIC VARIATION REGULATING SALMONELLA HOST-PATHOGEN INTERACTIONS AND DISEASE SUSCEPTIBILITYR01AI118903 · NIAID · DUKE UNIVERSITY · PI KO, DENNIS CHUN-YONE · 2015 to 2024
$4.2M
FCRL1 in B cell differentiationR15AI174170 · NIAID · MIAMI UNIVERSITY OXFORD · PI WILSON, TIMOTHY JAMES · 2023 to 2023
$412k
NIAID NIH HHS R01 AI118903NIAID NIH HHS R15 AI174170NIGMS NIH HHS T32 GM145449
6 · The paper itself

Abstract

Yersinia pestis is the bacterium responsible for plague, one of the deadliest diseases in history. To discover human genetic determinants of Y. pestis infection, we utilized nearly 1,000 genetically diverse lymphoblastoid cell lines in a cellular genome-wide association study. A nonsynonymous SNP, rs2282284 (N721S), in Fc receptor-like 3 (FCRL3) was associated with bacterial invasion of host cells (p = 9 × 10

Indexed as

PlagueReceptors, FcReceptors, ImmunologicYersinia pestisB-LymphocytesGenetic VariationGenome-Wide Association StudyHumansLymphocytesPolymorphism, Single NucleotideReceptors, Cell SurfaceReceptors, Cell SurfaceReceptors, FcReceptors, Immunologicbalancing selectionbubonic plagueFc receptorGWAShepatitis CHi-HOSThuman evolutionITAMLCLSYK

Identifiers

PMID40494344
PMCPMC12534707

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.