Evidence map›Paper›PMID 40494346›Full record

ArticleCell2025

Neuroendocrine cells orchestrate regeneration through Desert hedgehog signaling.

William Kong, Wan-Jin Lu, Megha Dubey, Rahul K Suryawanshi, Sivakamasundari Vijayakumar, Youngtae Jeong, Saurabh Gombar, Maximilian Diehn, Kunyoo Shin, Melanie Ott and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Neuroendocrine cells signal for repair: hedgehog leading the way.Signal transduction and targeted therapy · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

William KongInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Wan-Jin LuInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Megha DubeyDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Rahul K SuryawanshiGladstone Institutes, University of California, San Francisco, San Francisco, CA 94158, USA.
Sivakamasundari VijayakumarInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Youngtae JeongInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Saurabh GombarAtropos Health, Palo Alto, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Maximilian DiehnInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Kunyoo ShinInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Melanie OttGladstone Institutes, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Yueh-Hsiu ChienDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Kavita Y SarinDepartment of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Tushar J DesaiInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Internal Medicine, Division of Pulmonary, Allergy and Critical Care, Stanford University School of Medicine, Stanford, CA 94305, USA.
Philip A BeachyInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Departments of Urology, Developmental Biology, and (by courtesy) Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: pbeachy@stanford.edu.

Funding

Molecular mechanisms of Hedgehog receptor functionR01GM102498 · NIGMS · STANFORD UNIVERSITY · PI PHILIP A BEACHY · 2012 to 2026
$4.5M
Proliferation and Differentiation of Bladder Epithelial Cells in Regeneration and MalignancyR01CA157877 · NCI · STANFORD UNIVERSITY · PI BEACHY, PHILIP A · 2011 to 2022
$4.2M
Signal integration by specialized mesenchyme in urothelial homeostasis and Interstitial Cystitis / Bladder Pain SyndromeR01DK134989 · NIDDK · STANFORD UNIVERSITY · PI BEACHY, PHILIP A · 2022 to 2025
$3.0M
Hedgehog signaling in taste cell maintenance and regenerationR01DC016892 · NIDCD · STANFORD UNIVERSITY · PI BEACHY, PHILIP A · 2018 to 2022
$1.7M
MOLECULAR MECHANISMS OF HEDGEHOG RECEPTOR FUNCTIONR01HD039306 · NICHD · JOHNS HOPKINS UNIVERSITY · PI BEACHY, PHILIP A · 2000 to 2004
$1.7M
NCI NIH HHS R01 CA157877NICHD NIH HHS R01 HD039306NIDCD NIH HHS R01 DC016892NIDDK NIH HHS R01 DK134989NIGMS NIH HHS R01 GM102498
6 · The paper itself

Abstract

Understanding the mechanisms underlying mammalian regeneration may enable development of novel regenerative therapies. We present a mechanism wherein Desert hedgehog (Dhh), secreted from epithelial neuroendocrine cells, elicits a regenerative/protective response from mesenchymal cells. In mammalian airway, this mesenchymal response strikingly amplifies the initial signal from rare neuroendocrine cells to activate the entire tissue for survival and regeneration upon injury from SO

Indexed as

Hedgehog ProteinsNeuroendocrine CellsRegenerationSignal TransductionAnimalsCOVID-19HumansInsulin-Secreting CellsIslets of LangerhansMaleMiceMice, Inbred C57BLSARS-CoV-2StreptozocinHedgehog ProteinsStreptozocinairway inhalation injuryDesert hedgehogdiabetesHedgehog agonistHedgehog inhibitorinfluenzaneuroendocrine cellspancreatic islets of LangerhansregenerationSARS-CoV-2

Identifiers

PMID40494346
PMCPMC12232213

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.