Evidence map›Paper›PMID 40494997›Full record

ArticleThe EMBO journal2025

Transcription factor IRF-5 regulates lipid metabolism and mitochondrial function in murine CD8

Linh Thuy Mai, Sharada Swaminathan, Trieu Hai Nguyen, Etienne Collette, Tania Charpentier, Liseth Carmona-Pérez, Hamza Loucif, Alain Lamarre, Krista M Heinonen, David Langlais and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. The role of IRF5 as an immune regulator.Biochemical Society transactions · 2026
    Review
  2. Article
  3. CD8Cancer cell international · 2026
    Review
  4. Tumor-driven stabilization of CD8Frontiers in immunology · 2026
    Review
  5. TOPK Suppresses the CD8Cancer communications (London, England) · 2026
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Linh Thuy MaiCentre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, QC, Canada.
Sharada SwaminathanCentre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, QC, Canada.
Trieu Hai NguyenCentre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, QC, Canada.
Etienne ColletteDahdaleh Institute of Genomic Medicine, Department of Microbiology and Immunology, Department of Human Genetics, McGill University, Montreal, QC, Canada.
Tania CharpentierCentre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, QC, Canada.
Liseth Carmona-PérezCentre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, QC, Canada.
Hamza LoucifDepartment of Microbiology and Immunology, McGill University, Montréal, QC, Canada.
Alain LamarreCentre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, QC, Canada.
Krista M HeinonenCentre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, QC, Canada.ORCID http://orcid.org/0000-0002-2410-4432
David LanglaisDahdaleh Institute of Genomic Medicine, Department of Microbiology and Immunology, Department of Human Genetics, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-4429-0110
Jörg H FritzDahdaleh Institute of Genomic Medicine, Department of Microbiology and Immunology, Department of Human Genetics, McGill University, Montreal, QC, Canada.
Simona StägerCentre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, QC, Canada. simona.stager@inrs.ca.ORCID http://orcid.org/0000-0001-5508-9565

Funding

Armand-Frappier Foundation (Fondation Armand-Frappier) scholarshipCanadian Government | Canadian Institutes of Health Research (CIHR) PJT-148614Canadian Government | Canadian Institutes of Health Research (CIHR) PJT-168959Canadian Government | Canadian Institutes of Health Research (CIHR) PJT-175173Canadian Government | Canadian Institutes of Health Research (CIHR) PJT-190001FRQ | Fonds de Recherche du Québec - Santé (FRQS) scholarship
6 · The paper itself

Abstract

Exhaustion of CD8

Indexed as

CD8-Positive T-LymphocytesInterferon Regulatory FactorsLipid MetabolismLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMitochondriaAnimalsMiceMice, Inbred C57BLMice, KnockoutReactive Oxygen SpeciesInterferon Regulatory FactorsIrf5 protein, mouseReactive Oxygen SpeciesCD8 T CellsCell ExhaustionIRF-5Lipid MetabolismMitochondria

Identifiers

PMID40494997
PMCPMC12316916

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.