Evidence map›Paper›PMID 40495182›Full record

ReviewJournal of orthopaedic surgery and research2025

Research progress on exosomes from different sources in osteoarthritis and cartilage injury.

Zilong Yang, Zihao Deng, Wentao Gao, Wei Zhang, Xuxuan Fan, Ke Su, Zhiqin Liu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zilong YangJishou University Zhuzhou Clinical College, Medical College, Jishou University, Zhuzhou, Hunan, China.
Zihao DengJishou University Zhuzhou Clinical College, Medical College, Jishou University, Zhuzhou, Hunan, China.
Wentao GaoTrauma Center Department Three, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China.
Wei ZhangTrauma Center Department Three, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China.
Xuxuan FanTrauma Center Department Three, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China.
Ke SuTrauma Center Department Three, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China.
Zhiqin LiuTrauma Center Department Three, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China. zhiqin_liu@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are nanosized membrane vesicles secreted by cells that have garnered considerable attention in the biomedical field in recent years. Osteoarthritis (OA) is a common disabling joint disease with limited therapeutic options in clinical practice. Recent studies have shown that exosomes, as crucial mediators of intercellular communication, have proven effective in treating osteoarthritis and cartilage injury in vitro and in animal models. With ongoing research, exosomes have demonstrated tremendous potential in treating and even reversing osteoarthritis and cartilage injury. They may become an emerging therapeutic strategy in the future. This review primarily discusses the composition of exosomes and explores the potential mechanisms by which exosomes from different sources influence osteoarthritis and cartilage injury in the context of ongoing advances in exosome research. Furthermore, the review highlights the progress in exosome engineering for osteoarthritis Treatment to enhance the therapeutic efficacy of exosomes.

Indexed as

Cartilage, ArticularExosomesOsteoarthritisAnimalsCell CommunicationHumansCartilageCartilage injuryCell-Free therapyExosomesExtracellular vesiclesOsteoarthritis

Identifiers

PMID40495182
PMCPMC12153145

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.