Evidence map›Paper›PMID 40495387›Full record

ArticleBritish journal of haematology2025

Haematological parameters in erythropoietic protoporphyria: A multi-national study.

Rebecca K Leaf, Andrea Ricci, Benny Tran, Elena Corradini, Antonello Pietrangelo, Camilla Mancini, Cinzia Garuti, Dario Saltini, Filippo Schepis, Ilja Kubisch and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Rebecca K LeafDivision of Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-9978-8779
Andrea RicciRegional Reference Centre for the Diagnosis and Management of Porphyrias, Department of Medical and Surgical Science, Azienda Ospedaliero-Universitaria di Modena-Policlinico, University of Modena and Reggio Emilia, Modena, Italy.ORCID https://orcid.org/0000-0002-4812-3750
Benny TranDivision of Pulmonary & Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Elena CorradiniRegional Reference Centre for the Diagnosis and Management of Porphyrias, Department of Medical and Surgical Science, Azienda Ospedaliero-Universitaria di Modena-Policlinico, University of Modena and Reggio Emilia, Modena, Italy.
Antonello PietrangeloRegional Reference Centre for the Diagnosis and Management of Porphyrias, Department of Medical and Surgical Science, Azienda Ospedaliero-Universitaria di Modena-Policlinico, University of Modena and Reggio Emilia, Modena, Italy.
Camilla ManciniRegional Reference Centre for the Diagnosis and Management of Porphyrias, Department of Medical and Surgical Science, Azienda Ospedaliero-Universitaria di Modena-Policlinico, University of Modena and Reggio Emilia, Modena, Italy.
Cinzia GarutiRegional Reference Centre for the Diagnosis and Management of Porphyrias, Department of Medical and Surgical Science, Azienda Ospedaliero-Universitaria di Modena-Policlinico, University of Modena and Reggio Emilia, Modena, Italy.
Dario SaltiniEuropean Reference Network (ERN) Rare Liver.
Filippo SchepisEuropean Reference Network (ERN) Rare Liver.
Ilja KubischDepartment of Internal Medicine II, Porphyria Center, Klinikum Chemnitz, Chemnitz, Germany.
Nils WohmannDepartment of Internal Medicine II, Porphyria Center, Klinikum Chemnitz, Chemnitz, Germany.
Ulrich StölzelDepartment of Internal Medicine II, Porphyria Center, Klinikum Chemnitz, Chemnitz, Germany.
Paul Y JiangDivision of Pulmonary & Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-2016-6556
Samuel JangHarvard Medical School, Boston, Massachusetts, USA.
Narmene BensaberDivision of Pulmonary & Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Lina RebeizDivision of Pulmonary & Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Chenqing WangDivision of Pulmonary & Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Elizabeth BuzneyHarvard Medical School, Boston, Massachusetts, USA.
John TrinidadHarvard Medical School, Boston, Massachusetts, USA.
Karl E AndersonDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Texas Medical Branch, Galveston, Texas, USA.
Staffan WahlinEuropean Reference Network (ERN) EuroBloodNet.
Paolo VenturaRegional Reference Centre for the Diagnosis and Management of Porphyrias, Department of Medical and Surgical Science, Azienda Ospedaliero-Universitaria di Modena-Policlinico, University of Modena and Reggio Emilia, Modena, Italy.
Amy K DickeyHarvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-2979-9664

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Porphyrias Consortium: SupplementU54DK083909 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DESNICK, ROBERT J · 2009 to 2023
$18.5M
Measuring and Understanding Light Sensitivity in Erythropoietic ProtoporphyriaK23AR079586 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI YEUNG, AMY KATHRYN · 2021 to 2025
$875k
NCATS NIH HHS UL1 TR002541NCATS NIH HHS UL1TR002541NIAMS NIH HHS 1K23AR079586NIAMS NIH HHS K23 AR079586NIDDK NIH HHS U54 DK083909
6 · The paper itself

Abstract

Erythropoietic protoporphyria (EPP) is a disorder of haem biosynthesis characterized by a reduction in ferrochelatase and subsequent accumulation of protoporphyrin IX. Haematological aberrations in EPP have been described, though they remain poorly understood. We present a detailed analysis of haematological parameters in EPP, drawing upon data from four large cohorts in the United States and Europe. We show an association between protoporphyrin levels and both platelet count and spleen size, and in a case-control analysis, we describe significant differences between haematological indices in EPP patients versus controls.

Indexed as

EPPhaem biosynthesisiron metabolismporphyria

Identifiers

PMID40495387
PMCPMC12354258

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.