Trial reportBrain and behavior2025
High-Definition Transcranial Direct Current Stimulation Enhances Exercise-Induced Hypoalgesia in Healthy Individuals: An fNIRS Study.
Trial report in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Long-Lasting Changes of Repeated Anodal Transcranial Direct Current Stimulation in Decreasing Chronic Pain in Patients with Multiple Sclerosis: A Case Series.Brain sciences · 2026Article
- High-definition transcranial direct current stimulation enhances exercise-induced hypoalgesia in patients with chronic low back pain.iScience · 2026Article
- Dissociating the Role of Dorsolateral Prefrontal Cortex and Ventrolateral Prefrontal Cortex in Cognitive Control in Depression: A Combined HD-tDCS and fNIRS Study.Brain topography · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundThis study investigates whether anodal high-definition transcranial direct current stimulation (HD-tDCS) enhances exercise-induced hypoalgesia (EIH) and explores brain plasticity changes using functional near-infrared spectroscopy (fNIRS).
methodsThirty-nine participants were randomly assigned to either the active (n = 19) or sham HD-tDCS (n = 20) group. Both groups performed 25 min of moderate-intensity aerobic exercise followed by 20 min of either active or sham HD-tDCS applied to the left primary motor cortex (M1). PRIMARY OUTCOME: pressure pain threshold (PPT) at a local site. SECONDARY OUTCOMES: PPT at a remote site, cold pain threshold (CPT), and brain activation changes via fNIRS during the cold pressor test.
resultsBoth groups showed significant increases in PPT
conclusionHD-tDCS over M1 enhances EIH and is associated with increased brain activation in sensory-motor processing areas.
trial registrationClinical trial registration: ChiCTR2100048146.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.