Evidence map›Paper›PMID 40495661›Full record

SynthesisActa obstetricia et gynecologica Scandinavica2025

Efficacy and safety of laparoscopic lateral suspension with mesh for pelvic organ prolapse: A systematic review and meta-analysis.

Qi Wang, Stefano Manodoro, Xiaoxiang Jiang, Chaoqin Lin

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Acta obstetricia et gynecologica Scandinavica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
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  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qi WangDepartment of Gynecology, Fujian Maternity and Child Health Hospital, Fuzhou, People's Republic of China.ORCID 0000-0003-3175-2881
Stefano ManodoroASST Santi Paolo e Carlo, San Paolo Hospital, Milan, Italy.ORCID 0000-0002-1837-0806
Xiaoxiang JiangDepartment of Gynecology, Fujian Maternity and Child Health Hospital, Fuzhou, People's Republic of China.
Chaoqin LinDepartment of Gynecology, Fujian Maternity and Child Health Hospital, Fuzhou, People's Republic of China.ORCID 0000-0003-4631-0218

Funding

Joint Funds for the Innovation of Science and Technology, Fujian Province 2023Y9367
6 · The paper itself

Abstract

introductionLaparoscopic lateral suspension (LLS) with mesh is an alternative treatment for pelvic organ prolapse, offering enhanced apical vaginal suspension. This review aims to comprehensively evaluate the efficacy and safety of LLS for the treatment of pelvic organ prolapse through systematic review and meta-analysis. MATERIAL AND

methodsOriginal studies including randomized controlled trials, prospective, or retrospective studies reporting outcomes on the efficacy and safety of LLS with mesh for pelvic organ prolapse were retrieved from PubMed and Web of Science up to November 30, 2024. Case reports, reviews, and non-English literature were excluded. Primary outcomes included anatomical and subjective success rates. Secondary outcomes were recurrence rates, reoperation rates, and complications. Random-effects meta-analysis was performed where appropriate. This study has been registered in PROSPERO with the registration number CRD42024620632.

resultsEighteen studies (3 randomized controlled trials, 9 prospective studies, and 6 retrospective studies) involving 1430 LLS patients with a mean follow-up of 20.27 months were included. The pooled anatomical success rates for the apical and anterior compartments were 92.9% (95% confidence interval [CI]: 89.8-95.1) and 86.9% (95% CI: 81.4-90.9), respectively. The subjective success rate was 88.9% (95% CI: 85.3-91.7). The pooled recurrence rate was 9.6% (95% CI: 7.0-13.2), and the reoperation rate was 6.2% (95% CI: 4.3-8.9). Overall complication and mesh-related complication rates were 5.7% (95% CI: 3.4-9.4) and 1.9% (95% CI: 1.0-3.8), respectively. The incidence of Clavien-Dindo grade ≥3 complications was only 1.9% (16/848).

conclusionsLLS demonstrates favorable anatomical and subjective success rates, indicating its reliability and safety for pelvic organ prolapse treatment. However, longer follow-up is needed to validate its long-term efficacy.

Indexed as

Gynecologic Surgical ProceduresLaparoscopyPelvic Organ ProlapseSurgical MeshFemaleHumansPostoperative ComplicationsTreatment Outcomelaparoscopic lateral suspensionmeshpelvic organ prolapserecurrencesystematic review

Identifiers

PMID40495661
PMCPMC12393998

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.