Evidence map›Paper›PMID 40495824›Full record

ReviewCureus2025

Beyond the Biomedical Model: A Critical Review of the Approach to Chronic Pain and the Proposal of an Integrated Functional Model.

Luigi Pianese, Bruno Bordoni

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Luigi PianesePhysical Medicine and Rehabilitation, 3C+A Health and Rehabilitation, Roma, ITA.
Bruno BordoniPhysical Medicine and Rehabilitation, Foundation Don Carlo Gnocchi, Milan, ITA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic pain represents one of the most complex challenges of contemporary medicine. This narrative review critically analyzes the limitations of the traditional biomedical model in addressing chronic pain, highlighting how its reductionist vision is inadequate to effectively understand and treat this condition. The conceptual evolution of pain from a simple symptom to a codified "disease" is examined, highlighting the incongruities of this approach. The contribution of the bio-psycho-social model is discussed, recognizing its merits but also its applicative limits. Finally, the integration of the functional model, derived from functional medicine, is proposed as a complementary element that could fill the existing gaps, paying greater attention to nutritional and environmental factors and to the mesenchymal matrix as the biological "terrain" of chronic painful diseases. This review suggests the evolution towards a "bio-psycho-functional and social" model for a more complete understanding and management of chronic pain.

Indexed as

biomedical modelbio-psycho-social modelchronic headachefasciamyofascialpain

Identifiers

PMID40495824
PMCPMC12151456

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.