ArticleFrontiers in nutrition2025
Association between GNRI and risk of non-alcoholic fatty liver disease in non-obese individuals: a Chinese longitudinal prospective cohort study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Kaempferol Ameliorates Non-Alcoholic Fatty Liver Disease by Targeting TRIM56 to Regulate Lipid Metabolism.International journal of molecular sciences · 2026Article
- The novel nutritional metabolic risk index and established triglyceride-glucose indices in type 2 diabetes: modifying role of biological aging assessed by telomere length.Frontiers in nutrition · 2026Article
- The association between nutritional status, sarcopenia, and depressive symptoms in elderly Chinese patients receiving maintenance hemodialysis: a hospital-based cross-sectional study.Frontiers in nutrition · 2026Article
- Association of geriatric nutritional risk index with metabolic dysfunction-associated steatotic liver disease and subtypes in Chinese elderly: identification of an overnutrition risk threshold and implications for extended risk stratification.Frontiers in nutrition · 2026Article
- Association between the geriatric nutritional risk index and 28-day mortality in critically ill sepsis-associated pneumonia patients: retrospective study based on two cohorts.Frontiers in nutrition · 2025Article
- The mediating role of white matter hyperintensity in the association between malnutrition and cognitive impairment in patients with cerebral small vessel disease.Frontiers in neurologyArticle
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7 authors.
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Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disorder characterized by excessive hepatic fat accumulation without significant alcohol consumption. While obesity is a major risk factor, many non-obese individuals also develop NAFLD. However, research on this subgroup remains limited, and its underlying risk factors are unclear. Nutritional status plays a key role in NAFLD pathogenesis. The geriatric nutritional risk index (GNRI), widely used to assess nutrition, is linked to adverse health outcomes. However, its association with NAFLD in non-obese individuals remains poorly understood. Methods: A Results: The participants in higher GNRI groups had a higher risk of developing NAFLD, even after adjusting for confounding factors. This association was consistent across different body mass index (BMI) levels, although the trend was less significant in the higher BMI group. Furthermore, subgroup analysis revealed a consistent association between GNRI and NAFLD incidence in different sex, age, BMI, and systolic blood pressure (SBP) groups. However, there were some interactions observed in different alanine aminotransferase (ALT) groups. Conclusion: Our findings suggest that GNRI may serve as a useful indicator for predicting the risk of NAFLD in non-obese individuals, providing valuable insights for early detection and intervention strategies for this condition.
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