ArticleJournal of bacteriology2025
Functional consequences of genetic variations in DgoR, a GntR/FadR family transcriptional repressor of D-galactonate metabolism in
Article in Journal of bacteriology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Genetic variations in transcriptional regulators (TRs) of metabolic loci can influence host-bacterial interactions by affecting carbon utilization. Although the metabolism of sugar acids, including D-galactonate, is extensively implicated in the colonization and virulence of enteric bacteria, there has been no investigation on the extent of variations in their pathway-specific TRs. DgoR, the TR of D-galactonate metabolism, is the best-characterized GntR/FadR family sugar acid TR in enteric bacteria, recognized by the presence of an N-terminal winged helix-turn-helix DNA-binding domain and a C-terminal effector-binding and oligomerization (E-O) domain connected by a linker. Here, we examined 340
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