Evidence map›Paper›PMID 40497943›Full record

ReviewCells2025

Vasohibins in Health and Disease: From Angiogenesis to Tumorigenesis, Multiorgan Dysfunction, and Brain-Heart Remodeling.

Ghulam Abbas, Annet Kirabo, Usama Ahmed, Jie Liu, Jidong Chen

Abstract readReview
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ghulam AbbasGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen 518060, China.
Annet KiraboDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0001-8580-9359
Usama AhmedDepartment of Medicine, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen 518060, China.ORCID 0009-0008-3254-1537
Jie LiuGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen 518060, China.
Jidong ChenCollege of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.

Funding

Immune Mechanisms of Salt-Sensitive hypertensionR01HL144941 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KIRABO, ANNET · 2021 to 2025
$3.0M
Salt taste sensitivity, genetics and salt sensitivity of blood pressure in HIVR21TW012635 · FIC · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KIRABO, ANNET, MASENGA, SEPISO KENIAS · 2023 to 2024
$385k
FIC NIH HHS R21 TW012635National Natural Science Foundation of China [82370274, 81970054 (CJD)NHLBI NIH HHS R01 HL144941
6 · The paper itself

Abstract

Vasohibins (VASHs), comprising VASH-1 and VASH-2, were initially identified as regulators of angiogenesis. Recent studies, however, have unveiled their novel role in fibrosis and microtubule detyrosination. The dysregulated expression of VASHs is associated with several pathological processes, such as angiogenesis dysfunction, microtubule detyrosination, and fibrosis, contributing to various diseases. These findings suggest the pleiotropic effects of VASHs in multiple organs and systems beyond angiogenesis. This review explores the molecular properties of VASHs and their emerging functions in tubulin carboxyl activity and microtubule detyrosination-key to brain and cardiac remodeling. We also discuss the potential therapeutic applications of their interference in diseases such as tumorigenesis, as well as renal-, reproductive-, and liver-related diseases.

Indexed as

Angiogenic ProteinsBrainCarcinogenesisCell Cycle ProteinsNeovascularization, PathologicNeovascularization, PhysiologicVentricular RemodelingAngiogenesisAnimalsHumansAngiogenic ProteinsCell Cycle ProteinsVASH1 protein, humanangiogenesis regulatorcardiac/brain remodelingfibrosis TGF-β/SMAD pathwaymicrotubule detyrosinationvasohibins

Identifiers

PMID40497943
PMCPMC12153568

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.