Trial reportInternational orthopaedics2025
Perineural dexamethasone effectively prolongs anaesthesic block duration in total hip arthroplasty, reduces opioid consumption, and does not compromise motor function, nerve integrity, or glycaemic control.
Trial report in International orthopaedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Low-Volume Versus Standard-Volume Pericapsular Nerve Group Block with and Without Dexamethasone for Postoperative Analgesia After Total Hip Arthroplasty: A Randomized Controlled Trial.Journal of clinical medicine · 2026Article
- Comment on: "Perineural dexamethasone effectively prolongs anaesthesic block duration in total hip arthroplasty".International orthopaedics · 2026Article
- Article
- Combined ultrasound-guided C2 DRG pulsed radiofrequency and suboccipital myofascial plane block for cervicogenic headache: a retrospective study.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdequate postoperative analgesia is critical for elderly patients undergoing total hip arthroplasty (THA). The pericapsular nerve group (PENG) block relieves pain while preserving motor function, but its limited duration necessitates adjuncts. This study evaluates the efficacy of perineural dexamethasone in prolonging PENG block analgesia in geriatric THA patients.
methodsIn this double-blinded, randomized controlled trial, 60 patients (≥ 65 years) undergoing THA under spinal anaesthesia were assigned to the PENG group - PENG block with 20 mL 0.2% ropivacaine and the PENG + DEX group - PENG block with 20 mL 0.2% ropivacaine + 4 mg perineural dexamethasone. The primary outcome was time to first rescue opioid administration. The secondary outcomes included total opioid consumption, pain scores (NRS), quadriceps strength, and adverse effects over 48 h.
resultsDexamethasone significantly prolonged analgesia (16.0 ± 1.3 vs. 9.0 ± 1.7 h, p < 0.0001) and reduced opioid use (0.9 ± 1.2 vs. 2.1 ± 1.4 mEQ, p = 0.0003). Pain scores were lower at six, 12, and 24 h (p < 0.05). Quadriceps strength remained intact in both groups. No nerve injuries were observed (p > 0.9999). Blood glucose levels at 12, 24, and 48 h showed no significant differences between groups (p > 0.05).
conclusionsPerineural dexamethasone effectively prolongs PENG block duration, reduces opioid consumption, and does not compromise motor function, nerve integrity, or glycaemic control. It is a promising strategy for optimizing pain control in elderly THA patients.
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